Synthetic gene networks that count.
Synthetic gene networks that count.
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DOI：
10.1126/science.1172005
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发表时间：
2009-05-29
期刊：
影响因子：
--
通讯作者：
Collins JJ
中科院分区：
文献类型：
--
作者：
Friedland AE;Lu TK;Wang X;Shi D;Church G;Collins JJ
Synthetic gene networks can be constructed to emulate digital circuits and devices, giving one the ability to program and design cells with some of the principles of modern computing, such as counting. A cellular counter would enable complex synthetic programming and a variety of biotechnology applications. Here we report two complementary synthetic genetic counters in E. coli that can count up to three induction events, the first comprised of a riboregulated transcriptional cascade and the second of a recombinase-based cascade of memory units. These modular devices permit counting of varied user-defined inputs over a range of frequencies and can be expanded to count higher numbers.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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46.9
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通讯作者：
Stewart, AF
DOI：
10.1073/pnas.022039799
发表时间：
2002-04-02
影响因子：
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通讯作者：
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