Beyond the genome: RNA control of stem cells.
Beyond the genome: RNA control of stem cells.
复制标题
超越基因组：干细胞的 RNA 控制。
DOI：
10.1126/science.aaz4859
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Pyle,April
中科院分区：
文献类型：
--
作者：
Xi,Haibin;Pyle,April
Tissue-resident stem cells are important for maintaining proper organ and tissue function throughout the lifetime of mammals. Although some types of stem cells constantly proliferate and give rise to committed progeny, such as intestine and skin, others reside mainly in a quiescent (noncycling) state, such as skeletal muscle. How stem cells maintain their quiescence while contributing to homeostatic tissue turnover is not well understood and is an active topic of investigation because of the potential of stem cell biology in regenerative medicine and healthy aging (1). On page 734 of this issue, de Morreeet al.(2) characterize the underlying mechanisms that control muscle stem cell (MuSC) behavior in mice. Unexpectedly, they show that multiple species of RNAs coordinately confer precise regulation of quiescence and proliferation in MuSCs under homeostatic conditions.
