Corticotropin-Releasing Factor Acting at the Locus Coeruleus Disrupts Thalamic and Cortical Sensory-Evoked Responses
Corticotropin-Releasing Factor Acting at the Locus Coeruleus Disrupts Thalamic and Cortical Sensory-Evoked Responses
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DOI：
10.1038/npp.2012.50
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发表时间：
2012-08-01
影响因子：
7.6
通讯作者：
Valentino, Rita
中科院分区：
文献类型：
--
作者：
Devilbiss, David M.;Waterhouse, Barry D.;Valentino, Rita
压力和与压力相关的精神疾病，包括创伤后应激障碍，与感觉信息处理的破坏有关。神经肽促肾上腺皮质激素释放因子 (CRF) 在一定程度上通过激活蓝斑去甲肾上腺素 (LC-NE) 投射系统来协调对压力的生理和行为反应。尽管LC-NE系统是感觉信息处理的重要调节器，但迄今为止，该系统的CRF激活对感觉信号处理的影响仍知之甚少。目前的研究检查了清醒、自由活动大鼠丘脑和触须体感系统皮层内神经元自发放电和感觉诱发放电的 CRF 在 LC 上的剂量依赖性作用。 CRF 的 Peri-LC 输注导致腹侧后内侧丘脑和桶状区皮层神经元感觉诱发放电的剂量依赖性抑制。观察到自发活动同时增加。在将 NE 离子电渗疗法应用于目标神经元或刺激 LC-NE 通路时，通常不会发现后一种作用。两个区域内感觉诱发反应的信噪比净下降表明，在与 LC 处 CRF 释放相关的条件下（包括压力），感觉系统内传入信息的传递受到损害。严格地说，对某些类型的感官信息的抑制可能代表对即时的意外压力源的适应性反应。这种影响的持续存在可能会导致与压力和压力相关的精神病理学相关的感觉运动门控中出现的信息处理异常。神经精神药理学（2012）37，2020-2030； doi：10.1038/npp.2012.50； 2012 年 4 月 18 日在线发布
Stress and stress-related psychiatric disorders, including post-traumatic stress disorder, are associated with disruptions in sensory information processing. The neuropeptide, corticotropin-releasing factor (CRF), coordinates the physiological and behavioral responses to stress, in part, by activating the locus coeruleus-norepinephrine (LC-NE) projection system. Although the LC-NE system is an important modulator of sensory information processing, to date, the consequences of CRF activation of this system on sensory signal processing are poorly understood. The current study examined the dose-dependent actions of CRF at the LC on spontaneous and sensory-evoked discharge of neurons within the thalamus and cortex of the vibrissa somatosensory system in the awake, freely moving rat. Peri-LC infusions of CRF resulted in a dose-dependent suppression of sensory-evoked discharge in ventral posterior medial thalamic and barrel field cortical neurons. A concurrent increase in spontaneous activity was observed. This latter action is generally not found with iontophoretic application of NE to target neurons or stimulation of the LC-NE pathway. Net decreases in signal-to-noise of sensory-evoked responses within both regions suggest that under conditions associated with CRF release at the LC, including stress, the transfer of afferent information within sensory systems is impaired. Acutely, a suppression of certain types of sensory information may represent an adaptive response to an immediate unexpected stressor. Persistence of such effects could contribute to abnormalities of information processing seen in sensorimotor gating associated with stress and stress-related psychopathology. Neuropsychopharmacology (2012) 37, 2020-2030; doi:10.1038/npp.2012.50; published online 18 April 2012