Unexpected cause of raised benzene absorption in coke oven by-product workers
Unexpected cause of raised benzene absorption in coke oven by-product workers
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DOI：
10.1093/occmed/kqj034
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发表时间：
2006-06-01
影响因子：
5.1
通讯作者：
Coleman, Andrew
中科院分区：
文献类型：
--
作者：
Colman, Richard;Coleman, Andrew
背景：对焦炉副产物工人的苯进行尿液生物监测（通过测量苯代谢物）产生了意想不到的结果，10名工人中有2名尿中s -苯基巯基酸（S-PMA）显著升高。然而，同时进行的个人空气采样显示没有过量的空气暴露。方法排除吸入途径，对可能的原因进行研究。人们怀疑通过受污染的工作服的皮肤吸收是可能的机制，并引入了总体变化的标准频率。结果每四个班次后更换工作服可使所有员工的吸入剂量低于相当于1 ppm的吸入剂量。结论焦炉副产工人穿着污染工作服对苯的皮肤吸收显著，应定期频繁更换工作服。
Background Urinary biological monitoring for benzene (by measuring benzene metabolites) in coke oven by-product workers produced the unexpected result that 2 out of 10 employees had significantly raised urinary S-phenylmercapturic acid (S-PMA). However, simultaneous personal air sampling showed no excessive airborne exposure.Methods Possible causes for this finding were investigated having excluded inhalation as the route of uptake. It was suspected that skin absorption via contaminated overalls was the possible mechanism and a standard frequency for overall change was introduced.Results Changing overalls after every four shifts reduced uptake levels to less than the equivalent of 1 ppm inhaled dose for all employees.Conclusion Skin absorption of benzene in coke oven by-product workers from contaminated overalls can be significant and therefore overalls should be changed on a regular and frequent basis.