High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes.
High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes.
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DOI：
10.2337/db10-0598
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发表时间：
2011-01
期刊：
影响因子：
7.7
通讯作者：
Seaquist ER
中科院分区：
文献类型：
--
作者：
Franc DT;Kodl CT;Mueller BA;Muetzel RL;Lim KO;Seaquist ER
以前的研究已经观察到1型糖尿病患者大脑白色和灰质结构的破坏，这些结构差异与神经认知测试缺陷有关。本研究采用扩散张量成像（DTI）研究了一组1型糖尿病患者和健康对照者大脑皮质厚度减少与白色微结构完整性丧失之间的关系。25名1型糖尿病患者至少15年，25名年龄和性别匹配的对照组在3.0特斯拉扫描仪上进行结构T1和质子密度以及DTI。分数各向异性测量主要大脑白色物质束，并进行DTI纤维束成像，以确定与这些束的高连通性的皮质区域。后白色物质束的各向异性分数降低（视辐射，后冠辐射，和胼胝体压部区域）被发现有高度的连接与一些后皮质区域，包括楔，楔前叶，梭形，和后顶叶皮质区域。糖尿病组与视放射和后放射冠束高度连通的区域皮质厚度明显减少（P < 0.05）。白色和灰质结构病理学之间的直接关系以前尚未在长期1型糖尿病受试者中得到证实。后白色物质的微结构完整性破坏和较低的皮质厚度之间的关系表明，使用一种新的DTI连接技术的共同或相关的病理生理机制在1型糖尿病。
Previous studies have observed disruptions in brain white and gray matter structure in individuals with type 1 diabetes, and these structural differences have been associated with neurocognitive testing deficiencies. This study investigated the relationship between cerebral cortical thickness reductions and white matter microstructural integrity loss in a group of patients with type 1 diabetes and in healthy control subjects using diffusion tensor imaging (DTI). Twenty-five subjects with type 1 diabetes for at least 15 years and 25 age- and sex-matched control subjects underwent structural T1 and proton-density and DTI on a 3.0 Tesla scanner. Fractional anisotropy measurements were made on major cerebral white matter tracts, and DTI tractography was performed to identify cortical regions with high connectivity to these tracts. Posterior white matter tracts with reduced fractional anisotropy (optic radiations, posterior corona radiata, and the splenium region of the corpus callosum) were found to have high connectivity with a number of posterior cortical regions, including the cuneus, precuneus, fusiform, and posterior parietal cortical regions. A significant reduction in cortical thickness in the diabetic group was observed in the regions with high connectivity to the optic radiations and posterior corona radiata tracts (P < 0.05). The direct relationship between white and gray matter structural pathology has not been previously demonstrated in subjects with long-standing type 1 diabetes. The relationship between posterior white matter microstructural integrity disruption and lower cortical thickness demonstrated using a novel DTI connectivity technique suggests a common or interrelated pathophysiological mechanism in type 1 diabetes.