ALLOSTERIC PROTEINS AND CELLULAR CONTROL SYSTEMS
ALLOSTERIC PROTEINS AND CELLULAR CONTROL SYSTEMS
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DOI：
10.1016/s0022-2836(63)80091-1
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发表时间：
1963-01-01
影响因子：
5.6
通讯作者：
JACOB, F
中科院分区：
文献类型：
--
作者：
MONOD, J;CHANGEUX, JP;JACOB, F
许多蛋白质的生物活性是由特定的代谢物控制的，这些代谢物不直接与底物或反应产物相互作用。这些调节剂的作用似乎完全是由蛋白质结合该调节剂时诱导的构象改变（变构转变）引起的。这表明，这一机制在调节代谢活动中起着至关重要的作用，也可能在蛋白质合成的特定控制。
The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions. The effect of these regulatory agents appears to result exclusively from a conformational alteration (allosteric transition) induced in the protein when it binds the agent. It is suggested that this mechanism plays an essential role in the regulation of metabolic activity and also possibly in the specific control of protein synthesis.