Elastic interactions of cells
Elastic interactions of cells
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DOI：
10.1103/physrevlett.88.048102
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发表时间：
2002-01-28
影响因子：
8.6
通讯作者：
Safran, SA
中科院分区：
文献类型：
--
作者：
Schwarz, US;Safran, SA
软材料中的生物细胞可以模型化为各向异性的力收缩偶极子。相应的弹性相互作用势是长程的(类似于距离为r的1/r(3))，并且敏感地依赖于弹性常数、几何形状和细胞取向。在弹性衬底上，弹性相互作用在二维上类似于电四极子的相互作用，对于稠密系统，在细胞尺度上导致人字形有序的聚集。有限尺寸样品的自由表面和固定表面分别引入了吸引和排斥修正，这些修正在宏观尺度上是不同的。我们的理论预测了细胞在拉伸的弹性衬底上的重新定向。
Biological cells in soft materials can be modeled as anisotropic force contraction dipoles. The corresponding elastic interaction potentials are long ranged (similar to1/r(3) with distance r) and depend sensitively on elastic constants, geometry, and cellular orientations. On elastic substrates, the elastic interaction is similar to that of electric quadrupoles in two dimensions and for dense systems leads to aggregation with herringbone order on a cellular scale. Free and clamped surfaces of samples of finite size introduce attractive and repulsive corrections, respectively, which vary on the macroscopic scale. Our theory predicts cell reorientation on stretched elastic substrates.