Comparative Effects of Pranidipine with Amlodipine in Rats with Heart Failure
Comparative Effects of Pranidipine with Amlodipine in Rats with Heart Failure
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普拉地平与氨氯地平对心力衰竭大鼠的作用比较
DOI：
10.1159/000091746
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发表时间：
2006
期刊：
影响因子：
3.1
通讯作者：
Y. Aizawa
中科院分区：
文献类型：
--
作者：
P. Veeraveedu;Kenichi Watanabe;Meilei Ma;N. Gurusamy;S. Palaniyandi;J. Wen;Paras Prakash;M. I. I. Wahed;Fadia Kamal;Sayaka Mito;Megumi Kunisaki;M. Kodama;Y. Aizawa
本研究旨在比较长效钙通道拮抗剂pranidipine和tetrahydrofuran对自身免疫性心肌炎所致心力衰竭大鼠模型的心肌保护作用。免疫后28天，将存活大鼠随机经口给予低剂量丙戊酸钠（1 mg/kg/天）、高剂量丙戊酸钠（5 mg/kg/天）、普萘地平（0.3 mg/kg/天）或溶媒（0.5%甲基纤维素）。经口给药1个月后，对动物进行超声心动图和血流动力学分析。在心脏样本中进行组织学、免疫组织化学和Western免疫印迹。普萘地平和大剂量顺铂均能提高生存率。虽然心率在四组之间没有差异，但在pranidipine和高剂量amlodipine治疗的大鼠中，左心室舒张末期压显著降低，±dP/dt增加，但在低剂量amlodipine治疗的大鼠中没有。与顺铂治疗相比，pranidipine治疗显著降低了心肌细胞大小和中心静脉压。此外，pranidipine和高剂量的顺铂治疗显着降低心钠素和诱导型一氧化氮合酶的心肌蛋白水平，而pranidipine只显着降低肿瘤坏死因子-α，并提高肌浆网Ca 2 + ATP酶2蛋白水平。我们的结论是，pranidipine改善进展的左心室功能障碍和心脏重塑的大鼠在较低的剂量与自身免疫性心肌炎后心力衰竭相比，这可能是一个临床上潜在的治疗剂用于治疗心力衰竭。
The aim of the present study was to compare the cardioprotective properties of long-acting calcium channel antagonist pranidipine with amlodipine in rat model of heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization the surviving rats were randomized for the oral administration of low-dose amlodipine (1 mg/kg/day), high-dose amlodipine (5 mg/kg/day), pranidipine (0.3 mg/kg/day) or vehicle (0.5% methylcellulose). After oral administration for 1 month, the animals underwent echocardiography and hemodynamic analysis. Histopathology, immunohistochemistry, and Western immunoblotting were carried out in the heart samples. Both pranidipine and high-dose amlodipine increased survival rate. Although the heart rate did not differ among the four groups, left ventricular end-diastolic pressure was significantly decreased and ±dP/dt was increased in the pranidipine- and high-dose amlodipine-treated rats, but not in low-dose amlodipine-treated rats. In comparison to amlodipine treatment, pranidipine treatment significantly reduced myocyte size and central venous pressure. Furthermore, both pranidipine and high-dose amlodipine treatment significantly reduced myocardial protein levels of atrial natriuretic peptide and inducible nitric oxide synthase, whereas pranidipine only significantly decreased tumor necrosis factor-α, and improved sarcoplasmic reticulum Ca2+ATPase2 protein levels. We conclude that pranidipine ameliorates the progression of left ventricular dysfunction and cardiac remodeling in rats with heart failure after autoimmune myocarditis in a lower dose when compared to amlodipine and which may be a clinically potential therapeutic agent for the treatment of heart failure.
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心力衰竭发展期间的慢性氨氯地平治疗。
影响因子：
37.8
作者：
Spinale,FG;Mukherjee,R;Krombach,RS;Clair,MJ;Hendrick,JW;Houck,WV;Hebbar,L;Kribbs,SB;Zellner,JL;Dodd,MG
通讯作者：
Dodd,MG
影响因子：
37.8
作者：
J. P. Morgan;Raymond E. Erny;P. Allen;William Grossman;J. Gwathmey
通讯作者：
J. P. Morgan;Raymond E. Erny;P. Allen;William Grossman;J. Gwathmey
非衰竭和衰竭人类心室心肌中的β-肾上腺素能通路。
影响因子：
37.8
作者：
Bristow,MR;Hershberger,RE;Port,JD;Gilbert,EM;Sandoval,A;Rasmussen,R;Cates,AE;Feldman,AM
通讯作者：
Feldman,AM
DOI：
10.1016/s0021-9258(17)37600-7
发表时间：
1994-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Q. Xie;Y. Kashiwabara;C. Nathan
通讯作者：
Q. Xie;Y. Kashiwabara;C. Nathan
影响因子：
158.5
作者：
LEVINE, B;KALMAN, J;PACKER, M
通讯作者：
PACKER, M