A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes.
A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes.
复制标题
东南地区晚期痴呆住院患者生化参数与载脂蛋白E基因型关系的横断面研究
DOI：
10.2147/cia.s150283
复制
发表时间：
2018
影响因子：
3.6
通讯作者：
Li HL
中科院分区：
文献类型：
--
作者：
Jiang B;Zhang XP;Chen MF;Wang Z;Zhao MX;Chen BH;Li HL
本研究的目的是通过横断面调查分析晚期痴呆患者的疾病分布，并阐明载脂蛋白E（APOE）基因型与晚期阿尔茨海默病（AD）患者血清总胆固醇、总甘油三酯和血糖水平的关系。方法对某精神卫生中心的晚期痴呆患者进行研究。应用了一系列广泛的神经心理学测试和神经影像学来做出诊断。应用多重扩增突变系统聚合酶链反应检测APOE基因型。研究APOE基因型与血液生化指标的关系。结果共155例患者入组本研究。大多数患者患有AD（67.8%），其次是血管性痴呆（15.5%），混合性痴呆（9%）和其他（7.7%）。APOE ε4等位基因频率在不同年龄组间差异有统计学意义。APOE ε4携带者血清总胆固醇（TC）水平高于非携带者（P<0.05）。两组间血糖和甘油三酯（TG）水平无统计学显著差异。结论本研究首次对中国东南部地区晚期痴呆住院患者的特征进行了研究。我们发现，疾病分布与以前的患病率研究相当一致。此外，我们还发现APOE ε4携带者血清TC水平较高。而APOE ε4等位基因与AD晚期血糖、TC、TG水平无相关性。
Background The purpose of this study was to analyze the disease distribution of patients in the late stage of dementia through a cross-sectional investigation and to clarify the association between apolipoprotein E (APOE) genotypes and the serum levels of total cholesterol, total triglycerides, and blood glucose in the late-stage Alzheimer’s disease (AD) patients. Methods Patients who were in the late stage of dementia in a mental health center were enrolled in this study. A broad battery of neuropsychological tests and neuroimaging was applied to make the diagnosis. The APOE genotype was determined by the multiplex amplification refractory mutation system polymerase chain reaction. The association between APOE genotype and the blood level of biochemical parameters was studied. Results A total of 155 patients were enrolled in this study. The majority of patients had AD (67.8%), followed by vascular dementia (15.5%), mixed dementia (9%), and others (7.7%). The APOE ε4 allele frequency was significantly different in the different groups. The serum level of total cholesterol (TC) in APOE ε4 carriers was higher than in non-carriers (P<0.05). No statistically significant differences were found in the blood glucose and triglycerides (TG) levels between these two groups. Conclusion To our knowledge, this is the first paper to study the characteristics of late-stage dementia in hospital patients in Southeast China. We found that the disease distribution was quite consistent with previous prevalence studies. Moreover, we found that the serum level of TC was higher in APOE ε4 carriers group. However, no association was found between the APOE ε4 allele and serum levels of glucose, TC and TG in the late stage of AD.