ABC Transporters and the Alzheimer's Disease Enigma.
ABC Transporters and the Alzheimer's Disease Enigma.
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DOI：
10.3389/fpsyt.2012.00054
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发表时间：
2012
影响因子：
4.7
通讯作者：
Hartz AM
中科院分区：
文献类型：
--
作者：
Wolf A;Bauer B;Hartz AM
阿尔茨海默病（AD）被认为是“21世纪世纪的疾病”。在过去100年里，全球发病率增加了10倍，AD现已达到流行病的程度，根据所有预测，AD患者数量将继续增加。尽管进行了大量的研究，但AD仍然是一个谜，有效的治疗方法仍然不可用。这代表了未满足的需求，导致临床、社会和经济问题。在过去的十年中，出现了一个新的AD研究热点：ATP结合盒（ABC）转运蛋白。在这篇文章中，我们提供了ABC转运蛋白ABCA 1，ABCA 2，P-糖蛋白（ABCB 1），MRP 1（ABCC 1）和BCRP（ABCG 2）的概述，所有这些都在大脑中表达，并与AD有关。我们总结了这五种转运蛋白在AD中的作用，并讨论了它们作为治疗靶点的潜力。
Alzheimer’s disease (AD) is considered the “disease of the twenty-first century.” With a 10-fold increase in global incidence over the past 100 years, AD is now reaching epidemic proportions and by all projections, AD patient numbers will continue to rise. Despite intense research efforts, AD remains a mystery and effective therapies are still unavailable. This represents an unmet need resulting in clinical, social, and economic problems. Over the last decade, a new AD research focus has emerged: ATP-binding cassette (ABC) transporters. In this article, we provide an overview of the ABC transporters ABCA1, ABCA2, P-glycoprotein (ABCB1), MRP1 (ABCC1), and BCRP (ABCG2), all of which are expressed in the brain and have been implicated in AD. We summarize recent findings on the role of these five transporters in AD, and discuss their potential to serve as therapeutic targets.