Active experience, not time, determines within-day representational drift in dorsal CA1.
Active experience, not time, determines within-day representational drift in dorsal CA1.
复制标题
主动经验，而不是时间，决定了背侧 CA1 的一天内表征漂移。
DOI：
10.1016/j.neuron.2023.05.014
复制
发表时间：
2023
期刊：
影响因子：
16.2
通讯作者：
Derdikman,Dori
中科院分区：
文献类型：
--
作者：
Khatib,Dorgham;Ratzon,Aviv;Sellevoll,Mariell;Barak,Omri;Morris,Genela;Derdikman,Dori
过去事件的记忆可以在事件发生很久之后被回忆起来，这表明了稳定性。但新的经历也会整合到现有的记忆中，表明可塑性。在海马体中，空间表征被认为保持稳定，但也被证明在很长一段时间内会漂移。我们假设，经历，而不是时间的流逝，才是表征漂移背后的驱动力。我们比较了在不同持续时间内穿越两条相似、熟悉的路径的小鼠海马背侧CA1位置细胞表征在一天内的稳定性。我们发现，无论两次访问之间的总时间如何，动物花在积极穿越环境上的时间越多，表征漂移就越大。我们的研究结果表明，空间表征是一个动态过程，与特定情境下的持续经历有关，与记忆更新有关，而不是被动遗忘。
Memories of past events can be recalled long after the event, indicating stability. But new experiences are also integrated into existing memories, indicating plasticity. In the hippocampus, spatial representations are known to remain stable but have also been shown to drift over long periods of time. We hypothesized that experience, more than the passage of time, is the driving force behind representational drift. We compared the within-day stability of place cells' representations in dorsal CA1 of the hippocampus of mice traversing two similar, familiar tracks for different durations. We found that the more time the animals spent actively traversing the environment, the greater the representational drift, regardless of the total elapsed time between visits. Our results suggest that spatial representation is a dynamic process, related to the ongoing experiences within a specific context, and is related to memory update rather than to passive forgetting.