Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells
复制标题
DOI：
10.1039/c6cc08826k
复制
发表时间：
2017-02-04
影响因子：
4.9
通讯作者：
Kim, Yun Kyung
中科院分区：
文献类型：
--
作者：
Lim, Sungsu;Haque, Md. Mamunul;Kim, Yun Kyung
tau 聚集体的神经元积聚是多种神经退行性疾病（统称为 tau 病）的病理标志。可以监测神经元中异常 tau 聚集的 tau 聚集传感器将有助于 tau 聚集过程的研究和 tau 聚集阻滞剂的发现。在这里，我们描述了一种 BODIPY 荧光传感器（BD-tau），它选择性地响应活细胞中的病理性 tau 聚集体。
Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.