Electronic Cigarette Use and Respiratory Symptoms in Adolescents
Electronic Cigarette Use and Respiratory Symptoms in Adolescents
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DOI：
10.1164/rccm.201604-0804oc
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发表时间：
2017-04-15
影响因子：
24.7
通讯作者：
Berhane, Kiros
中科院分区：
文献类型：
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作者：
McConnell, Rob;Barrington-Trimis, Jessica L.;Berhane, Kiros
理由：青少年电子烟的使用率正在增加，但对使用的慢性影响的研究却很少。电子烟气溶胶的成分具有已知的肺部毒性。目的：调查青少年群体中使用电子烟与慢性支气管炎症状和喘息的关联。方法：对 2,086 名南加州儿童健康研究参与者在过去 12 个月内填写的问卷调查，调查了自我报告的电子烟使用与慢性支气管炎症状（慢性咳嗽、痰或支气管炎）和喘息的关联。 2014 年 11 年级和 12 年级。测量和主要结果：502 名学生 (24.0%) 报告曾经使用过电子烟，其中 201 名学生 (9.6%) 在过去 30 天内使用过电子烟（当前用户）。与从未使用过的人相比，过去使用过的人出现支气管炎症状的风险几乎增加了一倍（比值比 [OR]，1.85；95% 置信区间 [CI]，1.37-2.49），而当前使用者的支气管炎症状风险增加了 2.02 倍（95% CI，1.42-2.88）。与从不使用者相比，当前使用 1-2 天的风险随着当前使用频率的增加而增加（OR，1.66；95% CI，1.02-2.68），过去 30 天内使用 3 天或以上的风险随着当前使用频率的增加而增加，风险比为 2.52（95% CI，1.56-4.08）。通过调整终生吸烟数量和二手烟暴露，关联性被减弱。然而，在调整相关潜在混杂因素后，过去电子烟使用者出现支气管症状的风险仍然较高，并且在从不吸烟的使用者中也观察到这种情况（OR，1.70；95% CI，1.11-2.59）。调整香烟使用后，电子烟使用与喘息没有统计学上的显着关联。结论：青少年电子烟使用者慢性支气管炎症状的发生率增加。需要进一步调查以确定电子烟对呼吸系统健康的长期影响。
Rationale: Rates of adolescent electronic (e-) cigarette use are increasing, but there has been little study of the chronic effects of use. Components of e-cigarette aerosol have known pulmonary toxicity.Objectives: To investigate the associations of e-cigarette use with chronic bronchitis symptoms and wheeze in an adolescent population.Methods: Associations of self-reported use of e-cigarettes with chronic bronchitic symptoms (chronic cough, phlegm, or bronchitis) and of wheeze in the previous 12 months were examined in 2,086 Southern California Children's Health Study participants completing questionnaires in 11th and 12th grade in 2014.Measurements and Main Results: Ever e-cigarette use was reported by 502 (24.0%), of whom 201 (9.6%) used e-cigarettes during the last 30 days (current users). Risk of bronchitic symptoms was increased by almost twofold among past users (odds ratio [OR], 1.85; 95% confidence interval [CI], 1.37-2.49), compared with never-users, and by 2.02-fold (95% CI, 1.42-2.88) among current users. Risk increased with frequency of current use (OR, 1.66; 95% CI, 1.02-2.68) for 1-2 days and 2.52 (95% CI, 1.56-4.08) for 3 or more days in past 30 days compared with never-users. Associations were attenuated by adjustment for lifetime number of cigarettes smoked and secondhand smoke exposure. However, risk of bronchitic symptoms among past e-cigarette users remained elevated after adjustment for relevant potential confounders and was also observed among never-cigarette users (OR, 1.70; 95% CI, 1.11-2.59). There were no statistically significant associations of e-cigarette use with wheeze after adjustment for cigarette use.Conclusions: Adolescent e-cigarette users had increased rates of chronic bronchitic symptoms. Further investigation is needed to determine the long-term effects of e-cigarettes on respiratory health.