Heritabilities of symptoms of posttraumatic stress disorder, anxiety, and depression in earthquake exposed Armenian families
Heritabilities of symptoms of posttraumatic stress disorder, anxiety, and depression in earthquake exposed Armenian families
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DOI：
10.1097/ypg.0b013e3283060f48
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发表时间：
2008-12-01
影响因子：
0.9
通讯作者：
Bailey, Julia N.
中科院分区：
文献类型：
--
作者：
Goenjian, Armen K.;Noble, Ernest P.;Bailey, Julia N.
目的 研究遭受 1988 年亚美尼亚斯皮塔克地震影响的家庭成员中创伤后应激障碍 (PTSD)、焦虑、抑郁症状的遗传性，以及这些症状的共同遗传成分。 方法 对遭受过斯皮塔克地震影响的 12 个多代家庭的 200 名成员进行研究，使用电池组来评估地震暴露情况以及 PTSD、焦虑和抑郁症状。使用方差分量分析确定这些表型的遗传力，并使用双变量分析确定这些表型之间共有的遗传脆弱性。结果遗传力如下：PTSD 症状 41%（P
Objective To examine the heritabilities of symptoms of posttraumatic stress disorder (PTSD), anxiety, depression, and the shared genetic component of these symptoms among family members exposed to the 1988 Spitak earthquake in Armenia.Methods Two hundred members of 12 multigenerational families exposed to the Spitak earthquake were studied using a battery that assessed earthquake exposure and symptoms of PTSD, anxiety, and depression. Heritabilities of these phenotypes were determined using variance component analyses and shared genetic vulnerabilities between these phenotypes were determined using bivariate analyses.Results Heritabilities were as follows: PTSD symptoms 41% (P