Growth indices, anemia, and diet independently predict motor milestone acquisition of infants in South Central Nepal
Growth indices, anemia, and diet independently predict motor milestone acquisition of infants in South Central Nepal
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DOI：
10.1093/jn/135.12.2840
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Tielsch, JM
中科院分区：
文献类型：
--
作者：
Siegel, EH;Stoltzfus, RJ;Tielsch, JM
双足运动的获得是大运动发育的一个重要方面，最终影响幼儿的认知。存在营养相关变量与步行获得之间的关联的证据;然而，关于身高体重和饮食因素的重要性以及贫血和生长对步行的独立贡献的问题仍然存在。我们研究了营养因素对4至17个月大的尼泊尔儿童（n = 485）获得行走能力的影响，并对年龄、性别、种姓和社会经济地位（SES）进行了调整。参与者是从Sarlahi区1个村庄发展委员会收集的人口普查数据中确定的，并在2002年1月至3月期间参加了一项基于社区的跨部门研究。血红蛋白和红细胞原卟啉（EP）在基线时使用足跟穿刺技术进行测量。平均血红蛋白浓度为101 +/-12.5 g/L; 58%为贫血（血红蛋白<105 g/L），2.1%为严重贫血（血红蛋白<70 g/L），43%的儿童患有缺铁性贫血（血红蛋白<105 g/L; EP>= 90 μ mol/mol血红素）。生长延迟，即，33.7%发育不良，20.6%消瘦。控制年龄、性别、种姓和社会经济地位的多变量逻辑模型显示，具有较高的年龄别身高和身高别体重Z分数、无贫血和肉类消费的儿童比具有较低分数、贫血和无肉类消费的儿童在更早的年龄行走。我们的结论是，生长，贫血和饮食是独立的两足运动的尼泊尔儿童之间的发病延迟。
The acquisition of bipedal locomotion is an important aspect of gross motor development that ultimately affects the cognition of young children. Evidence for associations between nutrition-related variables and walking acquisition exist; however, questions remain about the importance of weight-for-length and dietary factors and the independent contribution of anemia and growth to walking. We examined the effect of nutritional factors on the acquisition of walking in a cross-sectional cohort of 4- to 17-mo old Nepali children (n = 485) adjusting for age, sex, caste, and socioeconomic status (SES). Participants were identified from census data collected in 1 village development committee in Sarlahi District and enrolled in a cross-sectional, community-based study between January and March 2002. Hemoglobin and erythrocyte protoporphyrin (EP) were measured at baseline using a heel-prick technique. The mean hemoglobin concentration was 101 +/- 12.5 g/L; 58% were anemic (hemoglobin < 105 g/L), 2.1 % were severely anemic (hemoglobin < 70 g/L), and 43% of the children had iron-deficiency anemia (hemoglobin < 105 g/L; EP >= 90 mu mol/mol heme). Growth was delayed, i.e., 33.7% were stunted and 20.6% were wasted. Multivariate logistic models that controlled for age, sex, caste, and SES revealed that children with higher length-for-age and weight-for-length Z-scores, no anemia, and meat consumption walked at an earlier age than children with lower scores, anemia, and no meat consumption. We conclude that growth, anemia, and diet are independently associated with delays in the onset of bipedal locomotion among young Nepali children.