Electronic device generated light increases reactive oxygen species in human fibroblasts
Electronic device generated light increases reactive oxygen species in human fibroblasts
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DOI：
10.1002/lsm.22794
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发表时间：
2018-08-01
影响因子：
2.4
通讯作者：
Jagdeo, Jared
中科院分区：
文献类型：
--
作者：
Austin, Evan;Huang, Amy;Jagdeo, Jared
目标我们的皮肤不断暴露在太阳辐射和电子设备的光线下，这会影响皮肤生理和衰老。紫外线 (UV) 太阳辐射对皮肤的生物改变特性已得到充分证实。电子设备产生的光 (EDGL) 对皮肤的影响引起了科学界和公众的极大兴趣。目前，EDGL 对皮肤的影响尚不清楚。 EDGL 包括来自智能手机、计算机和电视等消费电子产品的紫外线、可见光和红外线。在这项研究中，我们测量了电子设备的波长特定辐照度，并用白色 EDGL 照射成纤维细胞，以确定活性氧生成、细胞凋亡和坏死的变化。方法为了确定常用消费电子设备的 EDGL 输出，我们在制造商推荐的读取距离和 1 厘米处测量了电子设备的辐照度。为了确定 EDGL 对人类皮肤细胞的影响，我们用 EDGL 在 1cm 的距离照射 AG13145 成纤维细胞 1 小时，并测量活性氧生成、细胞凋亡和坏死的变化。结果 iPhone 8+、iPhone 6 和 iPad 上的白色 EDGL 照射 1 小时后，ROS 相对于对照显着增加了 81.71%、85.79% 和 92.98%（第一一代）分别。 iPhone 8+、iPhone 6 和 iPad 照射后细胞凋亡没有显着变化。所有治疗组和对照组的总坏死率低于 2%。结论我们的结果表明，短时间暴露于 EDGL 会增加 ROS 的产生，但与重复暴露于 EDGL 相关的长期影响尚不清楚。随着电子设备在全球范围内得到更广泛的使用和融入社会，我们预计会有更多的科学研究和公众对可见 EDGL 对皮肤的影响的兴趣。激光外科。医学。 50:689-695，2018 年。(c) 2018 Wiley 期刊公司。
ObjectivesOur skin is constantly exposed to light from solar radiation and electronic devices, which impact skin physiology and aging. The biological altering properties of ultraviolet (UV) solar radiation on skin have been well established. There is significant scientific and public interest on the effects of electronic device generated light (EDGL) on skin. Currently, the effects of EDGL on skin are largely unknown. EDGL includes UV, visible, and infrared light from consumer electronics such as smartphones, computers, and televisions. In this study, we measured the wavelength specific irradiance from electronic devices, and irradiated fibroblasts with white EDGL to determine changes in reactive oxygen species generation, apoptosis, and necrosis.MethodsTo determine the EDGL output of commonly used consumer electronic devices, we measured the irradiance from electronic devices at the manufacturers' recommended reading distances and at 1cm. To determine the effect of EDGL on human skin cells, we irradiated AG13145 fibroblasts with EDGL for 1hour at a distance of 1cm and measured changes in reactive oxygen species generation, apoptosis, and necrosis.ResultsROS increased significantly by 81.71%, 85.79%, and 92.98% relative to control following 1 hour of white EDGL from iPhone 8+, iPhone 6, and iPad (first generation), respectively. There was a non-significant change in apoptosis following irradiation with an iPhone 8+, iPhone 6, and iPad. Total necrosis was less than 2% for all treatment and control groups.ConclusionsOur results suggest that short exposures of EDGL increase ROS generation, but the long-term effects associated with repeated exposures of EDGL are unknown. As electronic devices become more widely used and integrated into society globally, we anticipate greater scientific research and general public interest on the effects of visible EDGL on skin. Lasers Surg. Med. 50:689-695, 2018. (c) 2018 Wiley Periodicals, Inc.