Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia.
Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia.
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DOI：
10.1364/ol.42.000867
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发表时间：
2017-02-15
期刊：
影响因子：
3.6
通讯作者：
Tearney GJ
中科院分区：
文献类型：
--
作者：
Cui D;Chu KK;Yin B;Ford TN;Hyun C;Leung HM;Gardecki JA;Solomon GM;Birket SE;Liu L;Rowe SM;Tearney GJ
我们报告了一种柔性、纵向扫描高分辨率显微光学相干断层扫描（μOCT）支气管内探头的设计和制造，该探头针对气道显微解剖成像进行了优化。2.4 mm直径和灵活性使其能够插入标准支气管镜的器械通道中，从而实现实时视频引导探头放置。为了产生焦深增强的环形光束，我们利用了一种新的制造方法，即中空玻璃套圈进行角度抛光和镀金，以产生细长的环形反射器。我们目前的验证数据，验证保存的线性扫描，尽管使用柔性材料。当用于离体培养的小鼠气管时，探头获得的图像质量与台式μOCT系统获得的图像质量相当。
We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (μOCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow glass ferrule was angle-polished and gold-coated to produce an elongated annular reflector. We present validation data that verifies the preservation of linear scanning, despite the use of flexible materials. When utilized on excised, cultured mouse trachea, the probe acquired images of comparable quality to those obtained by a benchtop μOCT system.