Brain organoids: the quest to decipher human-specific features of brain development.
Brain organoids: the quest to decipher human-specific features of brain development.
复制标题
大脑类器官：寻求破译人类大脑发育的特定特征。
DOI：
10.1016/j.gde.2022.101955
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发表时间：
2022
影响因子：
4
通讯作者：
Arlotta,Paola
中科院分区：
文献类型：
--
作者：
Uzquiano,Ana;Arlotta,Paola
人类大脑的发育主要发生在子宫内很长一段时间，因此无法通过实验进行;因此，需要易于处理的实验模型。人脑类器官已经成为研究人类大脑发育特征的强大模型系统。集中在大脑皮层，在这里，我们讨论了大脑，更具体地说，皮质，类器官模型如何新启用的祖细胞生物学和皮质细胞多样化方面的发现是人类独有的。我们预见，随着类器官生成的进步增加了这些模型的复杂性，更完整的大脑复制品将使未来的研究能够调查大脑生物学的高阶方面，从而了解人类大脑的独特处理能力。
The development of the human brain occurs largelyin uteroover long periods of time and is thus experimentally inaccessible; therefore, tractable experimental models are needed. Human brain organoid have emerged as powerful model systems to investigate human-specific features of brain development. Focusing on the cerebral cortex, here, we discuss how brain, and more specifically cortical, organoid models have newly enabled discovery of aspects of progenitor biology and cortical-cell diversification that are unique to humans. We foresee that as advancements in organoid generation increase the complexity of these models, more complete replicas of the brain will empower future studies investigating higher-order aspects of brain biology, toward an understanding of the unique processing capabilities of the human brain.