Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa.
Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa.
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DOI：
10.1371/journal.pone.0148958
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Paupy C
中科院分区：
文献类型：
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作者：
Boundenga L;Makanga B;Ollomo B;Gilabert A;Rougeron V;Mve-Ondo B;Arnathau C;Durand P;Moukodoum ND;Okouga AP;Delicat-Loembet L;Yacka-Mouele L;Rahola N;Leroy E;Ba CT;Renaud F;Prugnolle F;Paupy C
使用分子工具重新检查血孢子虫寄生虫的多样性（其中人类疟疾的病原体是最知名的）通常导致传统分类的重新排列。在这项研究中，我们探讨了血孢子虫寄生虫感染脊椎动物物种（特别是哺乳动物，鸟类和爬行动物）生活在加蓬（中非）的森林的多样性，通过分析收集的492个肉类样品。我们发现五种哺乳动物（四只小羚羊和一只穿山甲），一种鸟类和一种海龟的样本被血孢子虫寄生虫感染。在小羚羊中（大多数感染的标本都是从小羚羊中获得的），我们证明了至少存在两种与嗜多色菌属物种相关的不同寄生虫谱系（即，蝙蝠血孢子虫寄生虫）和蜥脚类疟原虫（来自鸟类和蜥蜴）。在纵向调查中捕获的森林蚊子的分子筛选发现，这些血孢子虫寄生虫谱系也存在于几个按蚊种，这表明在其传播的潜在作用。我们的研究结果表明，与以前认为的不同，血孢子虫寄生虫（疟原虫科）的几个独立分支感染哺乳动物，并通过按蚊传播。
Re-examination, using molecular tools, of the diversity of haemosporidian parasites (among which the agents of human malaria are the best known) has generally led to rearrangements of traditional classifications. In this study, we explored the diversity of haemosporidian parasites infecting vertebrate species (particularly mammals, birds and reptiles) living in the forests of Gabon (Central Africa), by analyzing a collection of 492 bushmeat samples. We found that samples from five mammalian species (four duiker and one pangolin species), one bird and one turtle species were infected by haemosporidian parasites. In duikers (from which most of the infected specimens were obtained), we demonstrated the existence of at least two distinct parasite lineages related to Polychromophilus species (i.e., bat haemosporidian parasites) and to sauropsid Plasmodium (from birds and lizards). Molecular screening of sylvatic mosquitoes captured during a longitudinal survey revealed the presence of these haemosporidian parasite lineages also in several Anopheles species, suggesting a potential role in their transmission. Our results show that, differently from what was previously thought, several independent clades of haemosporidian parasites (family Plasmodiidae) infect mammals and are transmitted by anopheline mosquitoes.