DJ-1 as a human oncogene and potential therapeutic target
DJ-1 as a human oncogene and potential therapeutic target
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DJ-1 作为人类癌基因和潜在的治疗靶点。
DOI：
10.1016/j.bcp.2014.11.012
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发表时间：
2015-02-01
影响因子：
5.8
通讯作者：
Yang, Bo
中科院分区：
文献类型：
--
作者：
Cao, Ji;Lou, Siyue;Yang, Bo
DJ-1是一种与癌症和帕金森氏病相关的蛋白，它参与不同的细胞内信号通路，保护细胞免受毒性应激的影响。在人类肿瘤中，DJ-1的表达、氧化、定位和磷酸化经常发生改变，DJ-1参与了肿瘤的多个方面的转化，包括失控的增殖、侵袭、转移、耐药和凋亡。尽管DJ-1与癌症有很强的关系，这使它成为癌症治疗的一个特别有吸引力的治疗靶点，但这种癌基因如何协调改变的信号与细胞生存的详细机制仍然不清楚。在这篇评论中，我们讨论了DJ-1在转化中的作用，强调了DJ-1信号在癌症治疗中的一些重要方面和前景，并描述了未来可能发生的情况。(C)2014 Elsevier Inc.保留所有权利。
DJ-1 is a cancer- and Parkinson's disease-associated protein that participates in different intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression, oxidation, localization, and phosphorylation are often altered in human tumors, and DJ-1 has been implicated in various aspects of transformation, including uncontrolled proliferation, invasion, metastasis, and resistance to chemotherapy and apoptosis. Despite the strong relationship between DJ-1 and cancer, which made it a particularly attractive therapeutic target for cancer treatment, the detailed mechanisms of how this oncogene coordinates altered signaling with cell survival remains elusive. In this commentary, we discuss the role of DJ-1 in transformation, highlight some of the significant aspects of and prospects for therapeutically targeting the DJ-1 signaling in cancer, and describe what the future may hold. (C) 2014 Elsevier Inc. All rights reserved.