Phylogenetic analysis supports horizontal gene transfer of L-amino acid oxidase gene in Streptococcus oligofermentans.
Phylogenetic analysis supports horizontal gene transfer of L-amino acid oxidase gene in Streptococcus oligofermentans.
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DOI：
10.1016/j.meegid.2012.02.014
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Hughes AL
中科院分区：
文献类型：
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作者：
Boggs JM;South AH;Hughes AL
对19种链球菌的10个氨基酸序列的系统发育分析表明，寡发酵链球菌属于mitis类群。然而，S. oligofmentans的l -氨基酸氧化酶（LAAO）的聚类模式与分析的其他蛋白质不同，暗示了S. oligofmentans LAAO基因的水平基因转移（HGT）起源。已知寡发酵葡萄球菌的LAAO赋予与其他口腔细菌竞争的能力，最明显的是变形葡萄球菌；因此，HGT事件可能在扩大该物种所占据的生态位方面发挥了重要作用，这与其他研究表明HGT在使细菌物种占据新的生态位方面发挥了关键作用相一致。
Phylogenetic analysis of 10 amino acid sequences from 19 Streptococcus species showed that S. oligofermentans clustered within the mitis group. However, the L-amino acid oxidase (LAAO) of S. oligofermentans showed a different clustering pattern from the other proteins analyzed implicating horizontal gene transfer (HGT) in the origin of the S. oligofermentans LAAO gene. LAAO of S. oligofermentans is known to confer ability to compete with other oral cavity bacteria, most notably S. mutans; therefore, the HGT event may have been important in extending the ecological niche occupied by this species, consistent with those of other studies suggesting that HGT can play a key role in enabling bacterial species to occupy new ecological niches.