Protecting-group-free S-glycosylation towards thioglycosides and thioglycopeptides in water.
Protecting-group-free S-glycosylation towards thioglycosides and thioglycopeptides in water.
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DOI：
10.1039/d1gc00098e
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发表时间：
2021-04-21
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Zhang GL;Gadi MR;Cui X;Liu D;Zhang J;Saikam V;Gibbons C;Wang PG;Li L
本研究开发了一种简便、绿色的无保护基、类水相酶促合成S-糖基化方法。以Ca（OH）2为促进剂，氟供体与巯基糖受体的糖基化反应以良好的产率和独特的立体选择性提供了各种硫代糖苷。该方法还能够成功生产S-连接的寡糖和S-连接的糖肽。
A facile and green S-glycosylation method has been developed featuring protecting-group-free and proceeding-in-water like enzymatic synthesis. Glycosylation of fluoride donors with thiol sugar acceptors using Ca(OH)2 as a promoter afforded various thioglycosides in good yields with exclusive stereoselectivity. This method also enabled the successful production of S-linked oligosaccharides and S-linked glycopeptides.