Catecholamine-induced stimulation of growth in Vibrio species
Catecholamine-induced stimulation of growth in Vibrio species
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DOI：
10.1111/j.1472-765x.2007.02136.x
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发表时间：
2007-06-01
影响因子：
2.4
通讯作者：
Nakaya, Y.
中科院分区：
文献类型：
--
作者：
Nakano, M.;Takahashi, A.;Nakaya, Y.
目的：为了评价去甲肾上腺素（NE）及其相关化合物对细菌生长的影响，我们研究了神经内分泌激素NE及其相关化合物对副溶血性弧菌和其他人类致病菌弧菌（霍乱弧菌、创伤弧菌和拟态弧菌）生长的影响。方法与结果：用血清培养基检测对细菌生长的影响，用琼脂平板计算活菌数。我们已经证明NE及其相关化合物在血清培养基中刺激副溶血性弧菌的生长。这种ne诱导的生长刺激依赖于转铁蛋白的存在。NE也能刺激拟弧菌的生长，但不能刺激霍乱弧菌和创伤弧菌的生长。结论：这些结果表明，不同种类的弧菌对NE的反应能力不同。研究的意义和影响：NE及其相关化合物可能调节副溶血性弧菌和拟溶血性弧菌的致病性。
Aims: To evaluate the effect of norepinephrine (NE) and related compounds on the growth of bacteria, we have examined the effect of the neuroendocrine hormone NE and related compounds on the growth of Vibrio parahaemolyticus and other human-pathogenic Vibrio species (Vibrio cholerae, Vibrio vulnificus, and Vibrio mimicus).Methods and Results: The effects on bacterial growth were examined using the serum-based medium and viable cells were counted using agar plates. We have shown that NE and its related compounds stimulate growth of V. parahaemolyticus in serum-based medium. This NE-induced growth stimulation was dependent upon the presence of transferrin. NE also stimulated growth of V. mimicus, but not V. cholerae and V. vulnificus.Conclusions: These results suggest that the Vibrio species differ in their ability to respond to NE.Significance and Impact of the Study: It is possible that NE and related compounds modulate the pathogenicity of V. parahaemolyticus and V. mimicus.