A cluster randomized controlled trial of an online psychoeducational intervention for people with a family history of depression
A cluster randomized controlled trial of an online psychoeducational intervention for people with a family history of depression
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DOI：
10.1186/s12888-018-1994-2
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发表时间：
2019-01-17
期刊：
影响因子：
4.4
通讯作者：
Mitchell, Philip B.
中科院分区：
文献类型：
--
作者：
Mills, Llewellyn;Meiser, Bettina;Mitchell, Philip B.
背景有抑郁症（MDD）或双相情感障碍（BD）家族史的人报告了现有在线干预无法满足的特殊心理教育需求。本试验旨在测试是否有抑郁症的家庭风险（干预）的人的互动网站将提高意向，通过，或实际通过，抑郁症预防策略（主要成果）和一系列的次要成果measurements.MethodsIn this cluster randomized trial，初级保健的病人被随机分配到要么提供链接到干预或控制网站。初级卫生保健与会者被邀请信选择进入这项研究，如果他们有至少一个一级亲属与MDD或BD，并被要求完成在线问卷在基线和2周follow-up.ResultsTwenty一般的做法是一个随机的，202名符合条件的患者完成了两份问卷。39名（19.3%）参与者为男性，163名（80.7%）为女性。在随访中，与对照组相比，干预组：（i）更有可能打算接受或实际接受心理治疗（OR=5.83，95%CI：1.58-21.47，p=.008）;（ii）对抑郁症危险因素和预防策略有更好的了解（平均差异=0.47，95%CI：0.05-0.88，p= 0.029）;和（iii）更可能准确地估计其发生BD的终生风险（平均差异=11.2，95%CI：-16.52--5.73，p
BackgroundPeople with a family history of major depressive disorder (MDD) or bipolar disorder (BD) report specific psychoeducational needs that are unmet by existing online interventions. This trial aimed to test whether an interactive website for people at familial risk for depression (intervention) would improve intention to adopt, or actual adoption of, depression prevention strategies (primary outcome) and a range of secondary outcome measures.MethodsIn this cluster randomised trial, primary care practises were randomised to either provide the link to the intervention or the control website. Primary health care attendees were invited by letter to opt into this study if they had at least one first-degree relative with MDD or BD and were asked to complete online questionnaires at baseline and 2-week follow-up.ResultsTwenty general practices were a randomized, and 202 eligible patients completed both questionnaires. Thirty-nine (19.3%) of participants were male and 163 (80.7%) female. At follow-up, compared to controls, the intervention group: (i) were more likely to intend to undergo, or to have actually undergone, psychological therapies (OR=5.83, 95% CI: 1.58-21.47, p=.008); (ii) had better knowledge of depression risk factors and prevention strategies (mean difference=0.47, 95% CI: 0.05-0.88, p=.029); and (iii) were more likely to accurately estimate their lifetime risk of developing BD (mean difference=11.2, 95% CI: -16.52- -5.73, p