Urinary Type IV Collagen in Nondiabetic Kidney Disease
Urinary Type IV Collagen in Nondiabetic Kidney Disease
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DOI：
10.1159/000319794
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发表时间：
2011-01-01
影响因子：
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通讯作者：
Rakugi, Hiromi
中科院分区：
文献类型：
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作者：
Furumatsu, Yoshiyuki;Nagasawa, Yasuyuki;Rakugi, Hiromi
背景：IV型胶原是基底膜的主要成分之一。在糖尿病肾病中，已知IV型胶原蛋白的尿排泄随着疾病进展而增加。然而，在非糖尿病肾病中，尿IV型胶原（u-IVc）水平尚未得到广泛研究。本研究的目的是评估u-IVc水平在各种肾病除糖尿病肾病。研究方法：通过一步夹心酶免疫测定法，对527例三级医院经活检证实的非糖尿病肾病患者的u-IVc水平进行横断面测量。结果如下：经单因素回归分析，u-IVc水平与年龄、血压、尿蛋白（u-Prot）、尿β 2微球蛋白、尿N-乙酰-β-D-氨基葡萄糖苷酶、HbA 1 c、选择性指数（SI）呈正相关，与eGFR、血清白蛋白呈负相关。多元回归分析显示，u-IVc与u-Prot、HbA 1 c、SI呈正相关。在活检证实的非糖尿病肾病中，在膜性肾病和抗中性粒细胞胞浆抗体（ANCA）相关性肾小球肾炎中明显观察到u-IVc升高。结论：u-IVc水平随u-Prot、HbA 1 c和SI的升高而升高。此外，在非糖尿病肾病中，在膜性肾病和ANCA患者中观察到u-IVc升高，这可能反映基底膜增厚或严重的肾损害。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Type IV collagen is one of the major components of basement membrane. In diabetic nephropathy, it is already known that urinary excretion of type IV collagen increases with the disease progression. However, in nondiabetic kidney disease, urinary type IV collagen (u-IVc) levels have not been extensively investigated. The aim of this study was to evaluate u-IVc levels in various nephropathies except diabetic nephropathy. Methods: u-IVc levels were measured cross-sectionally from 527 biopsy-proven nondiabetic renal disease patients at tertiary care hospitals by one-step sandwich enzyme immunoassay. Results: On simple regression analyses, u-IVc levels had positive correlation with age, blood pressure, urinary protein (u-Prot), urinary beta(2) microglobulin, urinary N-acetyl-beta-D-glucosaminidase, HbA(1)c, and selectivity index (SI), while u-IVc had negative correlation with eGFR and serum albumin. Multiple regression analyses revealed that u-IVc was positively correlated with u-Prot, HbA(1)c and SI. Among biopsy-proven nondiabetic nephropathies, elevation of u-IVc was distinctively observed in membranous nephropathy and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. Conclusion: u-IVc levels were elevated with the increase in u-Prot, HbA(1)c and SI. In addition, among nondiabetic kidney disease, elevation of u-IVc was observed in patients with membranous nephropathy and ANCA, which might reflect the thickening of basement membrane or severe kidney damage. Copyright (C) 2010 S. Karger AG, Basel