A Lamellar Unit of Aortic Medial Structure and Function in Mammals
A Lamellar Unit of Aortic Medial Structure and Function in Mammals
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DOI：
10.1161/01.res.20.1.99
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发表时间：
1967-01
影响因子：
20.1
通讯作者：
H. Wolinsky;S. Glagov
中科院分区：
文献类型：
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作者：
H. Wolinsky;S. Glagov
哺乳动物主动脉中层弹性蛋白、胶原蛋白和平滑肌的紧密结合导致了粘弹性特性，从而解释了其许多静态和动态机械特征。介质的结构成分精确定向在成分相当均匀的同心层或层状单元中。对 10 种哺乳动物（包括 15 种犬科动物）的成年胸主动脉进行的比较研究表明，成年哺乳动物主动脉中层的层状单位数量与主动脉半径几乎成正比，无论物种如何或测量的壁厚变化如何。估计的壁张力范围从 28 克小鼠的 7,820 达因/厘米到 200,000 克母猪的 203,000 达因/厘米，但主动脉中膜每个板层单位的平均张力无论物种如何都非常恒定，范围从 1,090 到 3,010 达因/厘米。研究结果表明，弹性蛋白层及其相邻层间区的内容物代表了哺乳动物主动脉壁的结构和功能单元。
The close association of elastin, collagen, and smooth muscle in the mammalian aortic media results in viscoelastic properties that account for many of its static and dynamic mechanical features. The structural components of the media are precisely oriented in concentric layers, or lamellar units, of fairly uniform composition. A comparative study of the adult thoracic aorta in 10 mammalian species, including 15 canine breeds, showed that the number of lamellar units in the media of adult mammalian aortas is very nearly proportional to aortic radius regardless of species or variations in measured wall thickness. Estimated wall tensions ranged from 7,820 dynes/cm in a 28-g mouse to 203,000 dynes/cm in a 200,000-g sow, but the average tension per lamellar unit of an aortic media was remarkably constant regardless of species, ranging from 1,090 to 3,010 dynes/cm. The findings suggest that the elastin lamella and the contents of its adjacent interlamellar zone represent the unit of structure and function of the mammalian aortic wall.