Sex differences in dopamine receptor overproduction and elimination
Sex differences in dopamine receptor overproduction and elimination
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DOI：
10.1097/00001756-199704140-00034
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发表时间：
1997-04-14
期刊：
影响因子：
1.7
通讯作者：
Teicher, MH
中科院分区：
文献类型：
--
作者：
Andersen, SL;Rutstein, M;Teicher, MH
多巴胺D-1和D-2家族受体的密度进行了评估，使用放射自显影在雄性和雌性大鼠从25日龄至120日龄，重点是从青春期到完全成年的过渡。男性有更大的过量生产（约4.6倍）和消除纹状体D-1和D-2受体比女性，虽然他们的成年密度非常相似。雄性大鼠中脑核中D-1受体的过度表达更为广泛，并在成年期内保持更高的密度（57.8 +/- 21.2%）。这些结果对于理解与多巴胺相关的临床疾病的患病率的性别差异具有意义。
Density of dopamine D-1 and D-2 family receptors was assessed using autoradiography in male and female rats from 25 to 120 days of age, focusing on transitions through puberty into full adulthood. Males had greater overproduction (approximately 4.6-fold) and elimination of striatal D-1 and D-2 receptors than females, though their adult densities were very similar. Males had more extensive overproduction of D-1 receptors in nucleus accumbens and sustained a greater density into adulthood (57.8 +/- 21.2%). These results have implications for understanding gender differences in the prevalence of clinical disorders associated with dopamine.