Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus
Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus
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DOI：
10.1021/es034983m
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发表时间：
2004-07-15
影响因子：
11.4
通讯作者：
Satoh, H
中科院分区：
文献类型：
--
作者：
Sakamoto, M;Kubota, M;Satoh, H
从甲基汞（MeHg）和n-3 PUFA（多不饱和脂肪酸）的角度来看，母体食用鱼类对胎儿既有风险又有益处。甲基汞是通过食用鱼类产生的最危险的物质之一，红细胞汞浓度（RBC-Hg）是甲基汞暴露的最佳生物标志物。二十二碳六烯酸（DHA，C22：6 n-3）是大脑正常发育和功能最重要的脂肪酸之一，也来自鱼类消费。本研究的目的是探讨分娩时母亲和胎儿红细胞汞与血浆脂肪酸组成的关系。在分娩时从63对母亲和胎儿（脐带血）中采集静脉血样本。在所有情况下，胎儿RBC汞水平高于母亲RBC汞水平。胎儿RBC汞的几何平均值为13.4ng/g，显著高于母体RBC汞的几何平均值（8.41ng/g）（P < 0.01）。虽然平均胎儿/母亲红细胞汞比为1.6，个别比率从1.08到2.19不等，这表明分娩时母亲和胎儿循环之间的甲基汞浓度存在相当大的个体差异。母体与胎儿DHA浓度呈显著正相关（r = 0.37，P < 0.01）。胎儿红细胞汞含量与血浆DHA含量呈显著正相关（r = 0.35，p < 0.01）。这些结果证实，甲基汞和DHA的来源于鱼类消费转移到母体的胎儿循环中，并存在于胎儿的循环呈正相关。孕妇尤其不需要为了获得这些好处而放弃吃鱼。但是，他们最好至少食用较小的鱼，因为这些鱼含有较少的甲基汞，从而平衡食用鱼类的风险和收益。
Maternal fish consumption brings both risks and benefits to the fetus from the standpoint of methylmercury (MeHg) and n-3 PUFA (polyunsaturated fatty acids). MeHg is one of the most risky substances to come through fish consumption, and mercury concentrations in red blood cells (RBC-Hg) are the best biomarker of MeHg exposure. Docosahexaenoic acid (DHA, C22:6n-3), which is one of the most important fatty acids for normal brain development and function, is also derived from fish consumption. Our objective in this study was to examine the relationships between RBC-Hg and plasma fatty acid composition in mother and fetus at parturition. Venous blood samples were collected from 63 pairs of mothers and fetuses (umbilical cord blood) at delivery. In all cases, fetal RBC-Hg levels were higher than maternal RBC-Hg levels. The geometric mean of fetal RBC-Hg was 13.4 ng/g, which was significantly (p < 0.01) higher than that of maternal RBC-Hg (8.41 ng/g). While the average fetal/maternal RBC-Hg ratio was 1.6, the individual ratios varied from 1.08 to 2.19, suggesting considerable individual differences in MeHg concentrations between maternal and fetal circulations at delivery. A significant correlation was observed between maternal and fetal DHA concentrations (r = 0.37, P < 0.01). Further, a significant correlation was observed between RBC-Hg and plasma DHA in fetus (r = 0.35, p < 0.01). These results confirm that both MeHg and DHA which originated from fish consumption transferred from maternal to fetal circulation and existed in the fetal circulation with a positive correlation. Pregnant women in particular need not give up eating fish to obtain such benefits. However, they would do well to at least consume smaller fish, which contains less MeHg, thereby balancing the risks and benefits from fish consumption.