WASH maintains NKp46(+) ILC3 cells by promoting AHR expression.
WASH maintains NKp46(+) ILC3 cells by promoting AHR expression.
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WASH 通过促进 AHR 表达维持 NKp46( ) ILC3 细胞
DOI：
10.1038/ncomms15685
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发表时间：
2017-06-07
影响因子：
16.6
通讯作者：
Fan Z
中科院分区：
文献类型：
--
作者：
Xia P;Liu J;Wang S;Ye B;Du Y;Xiong Z;Han ZG;Tong L;Fan Z
先天淋巴细胞 (ILC) 与其他造血和非造血细胞通讯，调节免疫、炎症和组织稳态。这些 ILC 谱系如何发展和维持尚不清楚。在这里，我们表明 WASH 在第 3 组 ILC (ILC3) 的细胞核中高度表达。 WASH 缺失会损害 NKp46+ ILC3 的细胞池。在 NKp46+ ILC3 中，WASH 将 Arid1a 招募到 Ahr 启动子，从而激活 AHR 表达。 ILC3 中的 WASH 缺失会减少 NKp46+ ILC3 的数量。此外，Arid1a 缺失会阻碍 AHR 表达并损害 NKp46+ ILC3 的维持。因此，WASH 介导的 AHR 表达在 NKp46+ ILC3 的维持中具有关键功能。人们认为先天淋巴细胞 (ILC) 可以指导免疫反应，但人们对 ILC 亚群的发育和维持知之甚少。在这里，作者表明，WASH 通过将 Arid1a 招募到芳烃受体启动子并诱导其表达来维持 NKp46+ ILC3 库。
Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46+ ILC3s. In NKp46+ ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases the number of NKp46+ ILC3s. Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NKp46+ ILC3s. Therefore, WASH-mediated AHR expression has a critical function in the maintenance of NKp46+ ILC3s. Innate lymphoid cells (ILC) are thought to direct immune responses, but little is known about the development and maintenance of ILC subsets. Here the authors show that WASH maintains the pool of NKp46+ ILC3s by recruiting Arid1a to the aryl hydrocarbon receptor promoter and inducing its expression.