Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2
Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2
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DOI：
10.1186/1471-2121-6-11
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发表时间：
2005-03-07
期刊：
影响因子：
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通讯作者：
Machesky, LM
中科院分区：
文献类型：
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作者：
Stovold, CF;Millard, TH;Machesky, LM
背景：Scar/WAVE蛋白家族通过直接激活Arp 2/3复合物介导肌动蛋白组装的信号。这些蛋白质已被表征为主要监管机构的片状伪足形成下游的Rac激活和作为成员的大型蛋白complexs.Results：我们已经调查了三个人的疤痕/波亚型的相互作用与几个先前描述的结合伙伴疤痕/波1或2。我们发现，所有三个疤痕/WAVE亚型的行为相似，并有可能参与相同种类的蛋白质复合物，调节actin assembly.Conclusion：疤痕/WAVE蛋白之间的差异，因此可能是在组织分布的水平上或在特异性结合伴侣的亲和力的细微差异。
Background: The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream of Rac activation and as members of large protein complexes.Results: We have investigated the interactions of the three human Scar/WAVE isoforms with several previously described binding partners for Scar/WAVE 1 or 2. We find that all three Scar/WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly.Conclusion: Differences between Scar/WAVE proteins are therefore likely to be at the level of tissue distribution or subtle differences in the affinity for specific binding partners.