Pathological and phylogenetic features of prevalent canine distemper viruses in wild masked palm civets in Japan
Pathological and phylogenetic features of prevalent canine distemper viruses in wild masked palm civets in Japan
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DOI：
10.1016/j.cimid.2008.07.003
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发表时间：
2009-12-01
影响因子：
2
通讯作者：
Kai, Chieko
中科院分区：
文献类型：
--
作者：
Takayama, Ikuyo;Kubo, Masahito;Kai, Chieko
对 2005 年至 2007 年在日本捕获的 10 只感染犬瘟热病毒 (CDV) 的野生果子狸进行了组织病理学和系统发育分析。基于果子狸两种 CDV 分离株 H 蛋白氨基酸序列的系统发育分析表明，这两种分离株属于日本近期分离株的进化枝。脑部存在组织病理学明显的病毒性脑炎病变，而胃肠道病变不存在或程度较轻。病变的分布与最近犬类 CDV 病例的分布相似。因此，最近果子狸中的 CDV 感染可能是由最近在狗中流行的 CDV 引起的。还讨论了果子狸作为野生动物中 CDV 传播者的可能性。 (C) 2008 Elsevier Ltd. 保留所有权利。
Ten wild masked palm civets infected with canine distemper virus (CDV), captured in Japan from 2005 to 2007, were histopathologically and phylogenetically analyzed. Phylogenetic analysis based on the amino acid sequences of the H protein of two CDV isolates from masked palm civets revealed that the two isolates were classified into the clade of recent isolates in Japan. Histopathologically marked lesions of virus encephalitis were present in the brain, whereas gastrointestinal lesions were absent or at a mild degree. The distribution of the lesions resembles that of recent CDV cases in dogs. Therefore, recent CDV infections in masked palm civets could be caused by recently prevalent CDV in dogs. The possibility of the masked palm civet as a spreader of CDV among wildlife is also discussed. (C) 2008 Elsevier Ltd. All rights reserved.