Dry powder vaccines for mucosal administration: critical factors in manufacture and delivery.
Dry powder vaccines for mucosal administration: critical factors in manufacture and delivery.
复制标题
用于粘膜给药的干粉疫苗：制造和交付的关键因素。
DOI：
10.1007/82_2011_167
复制
发表时间：
2012
影响因子：
--
通讯作者：
Staats,HermanF
中科院分区：
文献类型：
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作者：
Wang,SheenaH;Thompson,AftonL;Hickey,AnthonyJ;Staats,HermanF
干粉疫苗配方已被证明对诱导全身和粘膜免疫反应有效。本文综述了干疫苗在呼吸道免疫中的应用。我们讨论了粉末配方、制造、表征和输送技术，以及用于评估稳定性和安全性的方法。我们回顾了干粉疫苗的免疫原性和保护效果，并与粘膜或肠外途径的液体疫苗进行了比较。包括粘膜佐剂和粘膜黏合剂的信息，可用于增强鼻或肺干疫苗。使用干粉疫苗进行粘膜免疫，有可能提供一种无针和冷链独立的疫苗接种策略，以诱导针对全身或粘膜病原体的保护性免疫。
Dry powder vaccine formulations have proved effective for induction of systemic and mucosal immune responses. Here we review the use of dry vaccines for immunization in the respiratory tract. We discuss techniques for powder formulation, manufacture, characterization and delivery in addition to methods used for evaluation of stability and safety. We review the immunogenicity and protective efficacy of dry powder vaccines as compared to liquid vaccines delivered by mucosal or parenteral routes. Included is information on mucosal adjuvants and mucoadhesives that can be used to enhance nasal or pulmonary dry vaccines. Mucosal immunization with dry powder vaccines offers the potential to provide a needle-free and cold chain-independent vaccination strategy for the induction of protective immunity against either systemic or mucosal pathogens.