Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
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DOI：
10.1152/ajpendo.00540.2001
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发表时间：
2002-09-01
影响因子：
5.1
通讯作者：
Hagmüller, K
中科院分区：
文献类型：
--
作者：
Zaninovich, AA;Raíces, M;Hagmüller, K
研究了长期冷暴露对甲状腺功能减退大鼠棕色脂肪组织（BAT）产热的影响。在暴露于40 ℃ 2个月后，当BAT肥大和产热活动最大时，对正常大鼠进行甲状腺消融。消融术后，甲状腺功能减退和正常对照组在寒冷中再保持2个月。在4个月的冷暴露结束时，所有未治疗的甲状腺功能减退大鼠都活着，体温正常，体重比正常对照组平均增加12.8%。甲状腺功能减退大鼠长期冷暴露显着增加BAT重量，线粒体蛋白，解偶联蛋白（UCP）-1，mRNA的UCP-1，和氧消耗量的水平相似，在冷暴露的正常大鼠。结果表明，甲状腺激素需要增加产热能力发生作为一种适应长期冷暴露。然而，冷适应可以在缺乏甲状腺激素的情况下维持。
The effects of long-term cold exposure on brown adipose tissue (BAT) thermogenesis in hypothyroid rats have been examined. Thyroid ablation was performed in normal rats after 2 mo of exposure to 4degrees C, when BAT hypertrophy and thermogenic activity were maximal. After ablation, hypothyroid and normal controls remained in the cold for 2 additional months. At the end of the 4-mo cold exposure, all untreated hypothyroid rats were alive, had normal body temperature, and had gained an average 12.8% more weight than normal controls. Long-term cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats. The results indicate that thyroid hormones are required for increased thermogenic capacity to occur as an adaptation to long-term cold exposure. However, cold adaptation can be maintained in the absence of thyroid hormone.