Reduced lung function and risk of atrial fibrillation in The Copenhagen City Heart Study
Reduced lung function and risk of atrial fibrillation in The Copenhagen City Heart Study
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DOI：
10.1183/09031936.03.00051502
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发表时间：
2003-06-01
影响因子：
24.3
通讯作者：
Prescott, E
中科院分区：
文献类型：
--
作者：
Buch, P;Friberg, J;Prescott, E
慢性阻塞性肺疾病与心律失常的发生率高有关。很少有研究分析肺功能下降在预测房颤（AF）中的作用。本研究的目的是探讨一秒钟用力呼气量（FEV 1）与首次房颤发作风险之间的关系，对13，430名参加哥本哈根市心脏研究的既往无心肌梗死的男性和女性的数据进行了分析。新发房颤在5年后复查时进行评估，并在13年期间因房颤入院进行评估。采用多变量分析，调整心肺危险因素。5年随访时新发房颤62例（0.58%），住院时确诊290例（2.20%），调整性别、年龄、吸烟、血压、糖尿病和体重指数后，FEV 1为预测值的60-80%时复查时新发房颤的风险比FEV 1大于或等于80%时高1.8倍。当对教育、利尿剂治疗和活动时胸痛进行额外调整时，与FEV 1大于或等于80%相比，FEV 1在60-80%之间的房颤住院风险高1.3倍，FEV 1 < 60%的房颤住院风险高1.8倍。作者得出结论，肺功能降低是房颤事件的独立预测因素。
Chronic obstructive pulmonary disease has been associated with a high frequency of arrhythmias. Few studies have analysed the role of reduced lung function in predicting atrial fibrillation (AF). The aim of the present study was to investigate the relationship between forced expiratory volume in one second (FEV1) and risk of first episode of AF in a prospective study.Data from 13,430 males and females without previous myocardial infarction, who participated in the Copenhagen City Heart Study, were analysed. New AF was assessed at re-examination after 5 yrs and by hospital admission for AF during a period of 13 yrs. Multivariate analyses were used with adjustment for cardiopulmonary risk factors. There were 62 new cases of AF at 5-yr follow-up (0.58%) and 290 cases (2.20%) diagnosed at hospitalisations.Risk of new AF at re-examination was 1.8-times higher for FEV1 between 60-80% of predicted compared with FEV1 greater than or equal to 80%, after adjustment for sex, age, smoking, blood pressure, diabetes and body mass index. The risk of AF hospitallisation was 1.3-times higher for FEV1 between 60-80% and 1.8-times higher for FEV1 < 60% compared with FEV1 greater than or equal to 80%, when additional adjustment was made for education, treatment with diuretics and chest pain at activity. The authors conclude that reduced lung function is an independent predictor for incident atrial fibrillation.