Imaging of perfusion using ultrasound
Imaging of perfusion using ultrasound
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DOI：
10.1007/s00259-010-1537-7
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发表时间：
2010-08-01
影响因子：
9.1
通讯作者：
Lassau, Nathalie
中科院分区：
文献类型：
--
作者：
Cosgrove, David;Lassau, Nathalie
超声可以两种方式用于灌注成像：传统的使用多普勒和最近的使用微泡造影剂。多普勒使用简单，价格低廉，但仅限于流速较快的较大血管。它不能询问微血管系统，因为大量组织运动比毛细血管流动快。它已被用于肝脏和肿瘤流。对比研究更丰富，可以评估宏观和微循环。一种方法分析在团注静脉内注射之后感兴趣区域（例如肿瘤、心肌、脑）中的时间-强度曲线。另一种方法测量微泡穿过感兴趣的血管床所花费的时间。这些到达时间对于弥漫性和局灶性疾病中的肝脏以及肾脏都是有用的。静脉推注微泡后的时间-强度曲线的特征形成了肿瘤对抗血管药物的血管反应的敏感早期指标。这种方法被称为动态对比增强超声（DCE-US），已被多个权威机构接受为监测肿瘤反应的有效技术。
Ultrasound can be used to image perfusion in two ways: the traditional one using Doppler and the more recent using microbubble contrast agents. Doppler is simple to use and inexpensive but is limited to larger vessels with faster flow rates. It cannot interrogate the microvasculature because bulk tissue movement is faster than capillary flow. It has been used for liver and tumour flow. Contrast studies are much richer and can assess both the macro- and microcirculation. One approach analyses the time-intensity curves in a region of interest, e.g. a tumour, myocardium, brain, following bolus i.v. injection. Another approach measures the time taken for the microbubbles to cross a vascular bed of interest. These arrival times can be useful for the liver in both diffuse and focal diseases and for the kidney. Features derived from time-intensity curves following bolus i.v. injections of microbubbles form sensitive early indicators of the vascular response of tumours to antivascular drugs. This approach, known as dynamic contrast-enhanced ultrasound (DCE-US), has been accepted as a valid technique for monitoring tumour response by several authorities.