HABITUATION AND SENSITIZATION OF RAT STARTLE RESPONSE - EFFECTS OF RAPHE LESIONS
HABITUATION AND SENSITIZATION OF RAT STARTLE RESPONSE - EFFECTS OF RAPHE LESIONS
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DOI：
10.1016/0031-9384(74)90120-6
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发表时间：
1974-01-01
影响因子：
2.9
通讯作者：
SHEARD, MH
中科院分区：
文献类型：
--
作者：
DAVIS, M;SHEARD, MH
第一组实验中，假手术大鼠和未手术大鼠分别给予150吨（3个强度各50只），连续5天。各组之间在惊吓反应习惯率上没有发现差异，无论是在会议内还是会议之间。然而，中缝损伤后，惊吓的总体水平要高得多，逐个音调的分析表明，这是由中缝组中音调引起的敏感性增强引起的。在实验2中对惊吓致敏的进一步测试发现，raphe组比其他组对大声的音调和脚震更敏感，但对不同程度的背景白噪音则没有影响。研究结果支持了重复刺激暴露会产生习惯化和敏化的理论，这两个过程背后可能有不同的神经系统。
In the first experiment raphe lesioned, sham operated and nonoperated rats were presented with 150 tones (50 at each of 3 intensities) a day for 5 days. No differences were found among the groups in the rate of startle response habituation either within or between sessions. However, overall levels of startle were much greater following raphe lesions and a tone by tone analysis indicated that this was caused by heightened tone-elicited sensitization in the raphe group. Further tests of startle sensitization in Experiment 2 found the raphe group to be more sensitized than the other groups by loud tones and footshocks but not by different levels of background white noise. The results support the theory that repetitive stimulus exposure produces both habituation and sensitization and that different neural systems may underly these two processes.