Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker of Hashimoto's encephalopathy
Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker of Hashimoto's encephalopathy
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DOI：
10.1016/j.jneuroim.2005.02.004
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发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
Kuriyama, M
中科院分区：
文献类型：
--
作者：
Fujii, A;Yoneda, M;Kuriyama, M
我们研究了与桥本甲状腺炎相关的桥本脑病中的自身抗体及其表位。在蛋白质组学分析中，它们被证明可以识别α-烯醇化酶。我们使用在培养的人细胞中表达的重组蛋白的不同区域进一步搜索α-烯醇化酶中的表位区域。桥本氏脑病患者（83.3%; 5/6）的自体抗体识别氨基末端区域的比例远高于桥本氏甲状腺炎患者（11.8%; 2/17），而对照组（25名健康个体和25名患有其他神经系统疾病的对照组）的血清完全不识别氨基末端区域（0%; 0/50）。α-烯醇化酶的羧基末端和中间区域均未显示出对桥本脑病的特异性。抗α-烯醇化酶氨基末端的自身抗体是桥本脑病的有用诊断标志物。(C)2005 Elsevier B. V.保留所有权利。
We investigated autoantibodies and their epitope(s) in Hashimoto's encephalopathy associated with Hashimoto's thyroiditis. In a proteomic analysis, they proved to recognize alpha-enolase. We further searched the epitope region in alpha-enolase using different regions of recombinant proteins expressed in cultured human cells. The amino terminal region was recognized by autobodies from a much higher proportion of patients with Hashimoto's encephalopathy (83.3%; 5/6) than from patients with Hashimoto's thyroiditis (11.8%; 2/17), and not at all by sera from controls (25 healthy individuals and 25 controls with other neurological disorders) (0%; 0/50). Neither the carboxyl terminal nor the mid-region of alpha-enolase showed specificity for Hashimoto's encephalopathy. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker for Hashimoto's encephalopathy. (C) 2005 Elsevier B.V. All rights reserved.