Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?
Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?
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DOI：
10.1016/j.jalz.2006.03.001
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发表时间：
2006-07-01
期刊：
影响因子：
--
通讯作者：
Smith, Mark A
中科院分区：
文献类型：
--
作者：
Franco, Sonia;Blasco, Maria A;Smith, Mark A
阐明阿尔茨海默病的新方法，即使是那些有可靠数据的方法，当它们与主流或理论预期不同时，往往被忽视或视为现象现象而被驳回。在这里，我们提出了一个新的拼图，端粒长度的减少，端粒酶表达在已知易变性和阿尔茨海默病死亡的神经元群体。我们可以回答“是什么”的问题，但“为什么”、“何时”和“如何”就不那么容易回答了。本报告的目的是促进对这一发现的讨论和更深入的研究，使其成为治疗策略的新焦点。
New approaches to the elucidation of Alzheimer disease, even those with solid data, are often ignored or dismissed as epiphenomenal when they differ from the mainstream or theoretical expectations. Here we present a new piece to the puzzle, decreases in telomere length, and telomerase expression in neuronal populations known to be vulnerable to degeneration and death in Alzheimer's disease. We can present the answers to the question "what," but the "why," "when," and "how" are not so easily answered. The goal of this report is to prompt discussion and more intensive study of this finding toward a new focus of therapeutic strategy.