Chirality transferring [3,3] sigmatropic rearrangement of (1-Acyloxy-2-alkenyl)trianlkylsilane synthesis of optically active vinylsilane-containing alpha-amino acid.
Chirality transferring [3,3] sigmatropic rearrangement of (1-Acyloxy-2-alkenyl)trianlkylsilane synthesis of optically active vinylsilane-containing alpha-amino acid.
复制标题
(1-酰氧基-2-烯基)三烷基硅烷的手性转移[3,3]σ重排合成含光学活性乙烯基硅烷的α-氨基酸。
作者：
Kazuhiko Sakaguchi;Hiroyuki Suzuki;Y. Ohfune
通过α-酰氧基硅烷1的酯-烯式Claisen重排反应作为关键步骤，以光学活性的形式合成了含有乙烯基硅烷的α-氨基酸和α，α-二取代的α-氨基酸2，其中α-酰氧基-TBDMS的手性完全转移到重排产物上。
A vinylsilane-containing alpha-amino acid and alpha,alpha-disubstituted alpha-amino acid 2 having two contiguous asymmetric carbon centers at their alpha and beta positions were synthesized in an optically active form by ester-enolate Claisen rearrangement of the alpha-acyloxysilane 1 as the key step, where the chirality of an alpha-acyloxy-TBDMS group was completely transferred to the rearranged product.
影响因子：
56.9
作者：
CLELAND, WW;KREEVOY, MM
通讯作者：
KREEVOY, MM