Survival and death causes of patients with giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study
Survival and death causes of patients with giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study
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DOI：
10.1186/s13075-019-1945-4
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发表时间：
2019-06-25
影响因子：
4.9
通讯作者：
Gjesdal, C. G.
中科院分区：
文献类型：
--
作者：
Brekke, L. K.;Fevang, B. -T. S.;Gjesdal, C. G.
背景：我们的目的是确定巨细胞动脉炎（GCA）患者的生存率和死亡原因。方法：这是一项以医院为基础的回顾性观察队列研究，纳入了1972-2012年挪威西部诊断为GCA的患者。通过使用国际疾病分类（ICD）编码系统的计算机医院记录确定患者。审查了医疗记录。患者被随机分配到挪威中央人口登记处（CPRN）中年龄、性别和地理位置相匹配的人口对照组。死亡日期和原因来自挪威死亡原因登记处（NCoDR）。生存率采用Kaplan-Meier法和Gehan-Breslow检验进行分析，死亡原因采用累积发生率和Cox竞争风险模型进行分析。结果881例临床诊断为GCA，其中792例符合美国风湿病学会（ACR） 1990年的分类标准。在符合ACR标准的患者中，528人也接受了活组织检查。病例与2577例人口对照相匹配。在研究期间，共有490例（56%）GCA患者和1517例（59%）对照组死亡。我们发现，与对照组相比，GCA患者的总生存率没有差异，p=0.413。两组人中最常见的潜在死亡原因是循环系统疾病，其次是癌症。GCA患者死于循环系统疾病的风险增加(HR 1.31, 95% CI 1.13-1.51, p
BackgroundOur objective was to determine the survival and causes of death in a large and well-characterized cohort of patients with giant cell arteritis (GCA).MethodsThis is a hospital-based, retrospective, observational cohort study including patients diagnosed with GCA in Western Norway during 1972-2012. Patients were identified through computerized hospital records using the International Classification of Diseases (ICD)-coding system. Medical records were reviewed. Patients were randomly assigned population controls matched on age, sex, and geography from the Central Population Registry of Norway (CPRN). Date and cause of death were obtained from the Norwegian Cause of Death Registry (NCoDR). The survival was analyzed using Kaplan-Meier methods with the Gehan-Breslow test and the causes of death using cumulative incidence and Cox models for competing risks.ResultsWe identified 881 cases with a clinical diagnosis of GCA of which 792 fulfilled the American College of Rheumatology (ACR) 1990 classification criteria. Among those fulfilling the ACR criteria, 528 were also biopsy-verified. Cases were matched with 2577 population controls. A total of 490 (56%) GCA patients and 1517 (59%) controls died during the study period. We found no difference in the overall survival of GCA patients compared to controls, p=0.413. The most frequent underlying causes of death in both groups were diseases of the circulatory system followed by cancer. GCA patients had increased risk of dying of circulatory disease (HR 1.31, 95% CI 1.13-1.51, p