New insights into the activation of sterol regulatory element-binding proteins by proteolytic processing.
New insights into the activation of sterol regulatory element-binding proteins by proteolytic processing.
复制标题
DOI：
10.1515/bmc-2013-0009
复制
发表时间：
2013-08-01
影响因子：
--
通讯作者：
Sato, Ryuichiro
中科院分区：
文献类型：
--
作者：
Inoue, Jun;Sato, Ryuichiro
甾醇调节元件结合蛋白（SREBPs）是一种转录因子，可调控多种参与胆固醇和脂肪酸合成的基因。转录后，srebp在多个转录后水平受到控制，包括蛋白水解加工和翻译后修饰。其中，蛋白水解过程是激活SREBPs的关键调控步骤，SREBPs是作为无活性内质网膜蛋白合成的。在这篇综述中，我们重点介绍了通过蛋白水解过程影响SREBPs激活的信号通路和小分子的最新进展。
Abstract Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate a wide variety of genes involved in cholesterol and fatty acid synthesis. After transcription, SREBPs are controlled at multiple post-transcriptional levels, including proteolytic processing and post-translational modification. Among these, proteolytic processing is a crucial regulatory step that activates SREBPs, which are synthesized as inactive endoplasmic reticulum membrane proteins. In this review, we focus on recent progress with regard to signaling pathways and small molecules that affect activation of SREBPs by proteolytic processing.