Programming of a movement sequence in Parkinson's disease.
Programming of a movement sequence in Parkinson's disease.
复制标题
帕金森病运动序列的编程。
DOI：
10.1093/brain/120.1.91
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hefter,H
中科院分区：
文献类型：
--
作者：
Weiss,P;Stelmach,GE;Hefter,H
帕金森病患者的多成分运动的执行已被证明是受损的。为了确定这种缺陷是否归因于错误的运动编程，通过研究第一段的运动学来检查两段运动，当第二段包含可变的精度要求时。15名帕金森病患者的表现与年龄匹配的对照组进行了比较。运动精度不仅影响最后一节的运动学，也影响第一节的运动学。这种“背景效应”在两组中均被观察到。由于帕金森病患者显示出与对照组相似的运动模式，他们的运动编程似乎完好无损。此外，节段运动时间的相关性分析显示，两组中的高相关指数和低相关指数的主题。相关指数仅在帕金森病患者中与情境效应相关。与这些现象无关。帕金森病患者与对照组相比，在运动段之间表现出明显的犹豫，这表明他们在执行和/或在运动程序步骤之间切换时有困难。受损的力量控制和能力降低终止运动在帕金森氏病进行了讨论，作为可能的解释的缺陷，在电机程序的执行。
The execution of multiple-component movements has been shown to be impaired in Parkinson's disease patients. To determine whether this deficit is attributed to faulty motor programming, a two-segment movement was examined by studying the kinematics of the first segment when the second segment contained variable accuracy requirements. The performance of 15 Parkinson's disease patients was compared with an age-matched control group. Movement precision not only affected the kinematics of the final segment but also the kinematics of the first segment. This 'context effect' was observed in both groups. Since Parkinson's disease patients revealed similar movement patterns to those of controls, their motor programming appears to be intact. Furthermore, correlation analysis for the segment movement-times revealed subjects with high as well as low correlation indices in both groups. The correlation indices were related to the context effect only in the Parkinson's disease patients. Independent of these phenomenon. Parkinson's disease patients showed marked hesitations between the movement segments compared with controls, suggesting that they have difficulty in implementing and/or in switching between motor program steps. Impaired force control and a reduced capacity to terminate movements in Parkinson's disease are discussed as possible explanations of the deficit in motor program implementation.