Neonatal oxytocin manipulations have long-lasting, sexually dimorphic effects on vasopressin receptors
Neonatal oxytocin manipulations have long-lasting, sexually dimorphic effects on vasopressin receptors
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DOI：
10.1016/j.neuroscience.2006.09.009
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发表时间：
2007-01-05
期刊：
影响因子：
3.3
通讯作者：
Carter, C. S.
中科院分区：
文献类型：
--
作者：
Bales, K. L.;Plotsky, P. M.;Carter, C. S.
研究表明，在发育过程中暴露于催产素(OT)或催产素拮抗剂(OTA)会对草原田鼠(Microtus Ochrogaster)的社会行为造成持久的、往往是性别上的二态影响。由于一夫一妻制哺乳动物社会行为的调节涉及OT、精氨酸加压素(AVP)和多巴胺的中枢受体，我们检验了一种假设，即暴露于新生儿OT或OTA的长期发育影响可能反映了这些多肽受体表达的变化。出生后第1天，给草原田鼠腹腔注射OT(1 mg/kg)、OTA(0.1 mg/kg)、生理盐水或单独处理。在大约60日龄时，用受体放射自显影技术对雄性和雌性大鼠脑组织中的加压素V1a受体、催产素受体和多巴胺D2受体结合进行了定量。终纹床核(BNST)、扣带回皮质(CgCtx)、丘脑内侧背侧核(MdThal)、下丘脑视前内侧区(MPOA)和外侧隔核(LS)对V1a结合有显著影响。CgCtx、MPOA、腹侧苍白球和LS在V1a结合上的处理交互作用也表现出显著的性行为。未观察到D2受体结合的显著处理或性别差异。在OTR受体结合方面，没有观察到显著的治疗差异，只有边缘性别差异。神经肽受体表达的变化，特别是V1a受体的变化，可能有助于解释类似的新生儿操作后行为的性二态变化。(C)2006年IBRO。爱思唯尔有限公司出版。保留所有权利。
Developmental exposure to oxytocin (OT) or oxytocin antagonists (OTAs) has been shown to cause longlasting and often sexually dimorphic effects on social behaviors in prairie voles (Microtus ochrogaster). Because regulation of social behavior in monogamous mammals involves central receptors for OT, arginine vasopressin (AVP), and dopamine, we examined the hypothesis that the long-lasting, developmental effects of exposure to neonatal OT or OTA might reflect changes in the expression of receptors for these peptides. On postnatal day 1, prairie voles were injected intraperitoneally with either OT (1 mg/kg), an OTA (0.1 mg/kg), saline vehicle, or were handled only. At approximately 60 days of age, vasopressin V1a receptors, OT receptors (OTR) and dopamine D2 receptor binding were quantified using receptor autoradiography in brain tissue taken from males and females. Significant treatment effects on V1a binding were found in the bed nucleus of the stria terminalis (BNST), cingulate cortex (CgCtx), mediodorsal thalamus (MdThal), medial preoptic area of the hypothalamus (MPOA), and lateral septum (LS). The CgCtx, MPOA, ventral pallidum, and LS also showed significant sex by treatment interactions on V1a binding. No significant treatment or sex differences were observed for D2 receptor binding. No significant treatment difference was observed for OTR receptor binding, and only a marginal sex difference. Changes in the neuropeptide receptor expression, especially the V1a receptor, may help to explain sexually dimorphic changes in behavior that follow comparable neonatal manipulations. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.