The possible effect of clinical recovery regional cerebral blood flow deficits in fibromyalgia:: A prospective study with semiquantitative SPECT
The possible effect of clinical recovery regional cerebral blood flow deficits in fibromyalgia:: A prospective study with semiquantitative SPECT
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DOI：
10.1097/00007611-200407000-00008
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发表时间：
2004-07-01
影响因子：
1.1
通讯作者：
Nacitarhan, V
中科院分区：
文献类型：
--
作者：
Adigüzel, O;Kaptanoglu, E;Nacitarhan, V
目的：在一些纤维肌痛研究中报告了脑血流量的局部缺陷;然而，没有关于治疗和临床恢复对这些异常的影响的信息。我们评估了阿米替林治疗和随后的临床恢复对脑血流量的变化在fibromyalgin.Methods：我们评估了脑血流量与半定量功能脑映射技术的单光子发射计算机断层扫描在14例原发性纤维肌痛阿米替林治疗前后3个月。采用视觉模拟评分、压痛点计数、比克抑郁量表对患者的临床改善情况进行随访。贝克抑郁量表没有显著变化。治疗后，单光子发射计算机断层扫描观察到双侧半丘脑和基底神经节的血流量统计学显着增加，而双侧颞叶、左颞枕叶和右枕叶的血流量减少。结论：我们推测这些发现可能表明纤维肌痛的脑血流量缺陷与临床恢复平行改善。
objectives: Regional deficits in cerebral blood flow have been reported in a few studies of fibromyalgia; however, there is no information on the effects of treatment and clinical recovery on these abnormalities. We evaluated the effects of amitriptyline treatment and consequent clinical recovery on cerebral blood flow changes in fibromyalgia.Methods: We assessed cerebral blood flow with a semiquantitative functional brain mapping technique of single-photon emission computed tomography in 14 patients with primary fibromyalgia before and after 3 months of amitriptyline treatment. Patients were followed by visual analog scale, tender point count, and Beek Depression Inventory for clinical improvement.Results: There was statistically significant improvement in visual analog scale and tender point count after treatment. Beck Depression Inventory did not change significantly. Statistically significant blood flow increase in bilateral hemithalami and basal ganglia and decrease in bilateral temporal, left temporo-occipital, and right occipital lobes were observed on single-photon emission computed tomography after treatment.Conclusions: We speculate that these findings could indicate that deficits in cerebral blood flow in fibromyalgia improve parallel to clinical recovery.