Depression after diagnosis of advanced non-small cell lung cancer and survival: A pilot study
Depression after diagnosis of advanced non-small cell lung cancer and survival: A pilot study
复制标题
DOI：
10.1176/appi.psy.49.3.218
复制
发表时间：
2008-05-01
期刊：
影响因子：
3.4
通讯作者：
Lynch, Thomas J.
中科院分区：
文献类型：
--
作者：
Pirl, William F.;Temel, Jennifer S.;Lynch, Thomas J.
背景资料：据估计，重度抑郁症发生在10%-25%的癌症患者中，并且与死亡率增加不一致。目的：本初步研究探讨晚期非小细胞肺癌（NSCLC）患者抑郁与生存率的关系。方法：采用医院焦虑抑郁量表对43例晚期非小细胞肺癌患者进行前瞻性随访。结果：抑郁症患者生存率低。中位生存期比没有抑郁症的人短四倍。控制基线表现状态，抑郁症预测6个月死亡率，但对总生存率无显著影响。结论：虽然晚期NSCLC诊断后抑郁与6个月生存率相关，但这种相关性不存在于总生存率中;然而，应进行更大样本的进一步研究。
Background: Major depressive disorder is estimated to occur in 10%-25% of people with cancer and it has been inconsistently linked to increased mortality. Objective: This pilot study investigates the association of depression and survival in advanced non-small cell lung cancer (NSCLC) patients. Method: Forty-three recently-diagnosed advanced NSCLC patients completed the Hospital Anxiety and Depression Scale and were followed prospectively. Results: Patients with depression had poorer survival. Median survival was four times shorter than those without depression. Controlling for baseline performance status, depression predicted 6-month mortality, but was not significant for overall survival. Conclusion: Although depression after advanced-NSCLC diagnosis was associated with poorer survival at 6 months, this association was not present for overall survival; however, further research with larger samples should be pursued.