MultiFun, a multifunctional classification scheme for Escherichia coli K-12 gene products
MultiFun, a multifunctional classification scheme for Escherichia coli K-12 gene products
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DOI：
10.1089/omi.1.2000.5.205
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Riley, Monica
中科院分区：
文献类型：
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作者：
Serres, Margrethe Hauge;Riley, Monica
在Riley分类法的基础上，建立了大肠杆菌K-12基因产物细胞功能的富集分类系统。在新的分类方案中，MultiFun将细胞功能分为10大类：代谢，信息传递，调节，运输，细胞过程，细胞结构，位置，染色体外起源，DNA位点和隐藏基因。这些主要类别又进一步细分为一个等级制度。2922个E. coli K-12中的一种或多种功能，这取决于它们在细胞中发挥的作用。66%的E.大肠杆菌基因产物，范围从1到16分配每个基因产物。细胞功能类别的扩展和分配到一个以上的类别（多功能）提供了一个更完整的描述的基因产物及其作用，因此更好地反映了生物体的功能复杂性。我们相信，这种分类系统将是有用的基因组分析领域，无论是注释的目的和比较研究。本文对E.大肠杆菌基因产物可以从网上的数据库GenProtEC（http：//www.example.com）和EcoCyc（http：www.ecocyc.org）获得。genprotec.mbl.edu
An enriched classification system for cellular functions of gene products of Escherichia coli K-12 was developed based on the initial classification by Riley. In the new classification scheme, MultiFun, cellular functions are divided into 10 major categories: Metabolism, Information Transfer, Regulation, Transport, Cell Processes, Cell Structure, Location, Extra-chromosomal Origin, DNA Site, and Cryptic Gene. These major categories are further subdivided into a hierarchical scheme. Two thousand nine hundred twenty-two gene products of E. coli K-12 were assigned to one or more functions depending on the role they play in the cell. Functional assignments were made to 66% of E. coli gene products, ranging from 1 to 16 assignments per gene product. The expansion of cellular function categories and the assignment to more than one category (multifunction) provides a more complete description of the gene products and their roles and hence better reflects the functional complexity of organisms. We believe this classification system will be useful in the field of genome analysis, both for annotation purposes and for comparative studies. The functional classification scheme and the cellular function assignments made to E. coli gene products can be accessed from the web at the databases GenProtEC (http://genprotec.mbl.edu) and EcoCyc (http://www.ecocyc.org).