Are adaptive mutations due to a decline in mismatch repair? The evidence is lacking.
Are adaptive mutations due to a decline in mismatch repair? The evidence is lacking.
复制标题
适应性突变是否是由于错配修复能力下降所致？
DOI：
10.1016/s1383-5742(98)00023-4
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Foster,PL
中科院分区：
文献类型：
--
作者：
Foster,PL
在大肠杆菌的稳定期和营养匮乏的细胞中，甲基定向错配修复所需的蛋白质水平似乎下降。有人假设，系统的纠错能力也会下降，这种下降是适应性突变或静止突变的原因。然而，支持这一假设的证据是缺乏的。错配修复系统在长时间选择过程中纠正错误的效率不亚于在生长过程中。此外，过量供应的错配修复蛋白减少生长依赖性和适应性突变。
The levels of proteins required for methyl-directed mismatch repair appear to decline in stationary-phase and nutritionally-deprived cells of Escherichia coli. It has been hypothesized that error-correction by the system also declines, and this decline is responsible for adaptive or stationary-phase mutations. However, evidence in support of this hypothesis is lacking. The mismatch repair system is no less effective in correcting errors during prolonged selection than it is during growth. Furthermore, mismatch repair proteins supplied in excess reduce both growth-dependent and adaptive mutation.