The Relationships Between Plasma and Red Cell Vitamin B2 and B6 Concentrations and the Systemic and Local Inflammatory Responses in Patients With Colorectal Cancer
The Relationships Between Plasma and Red Cell Vitamin B2 and B6 Concentrations and the Systemic and Local Inflammatory Responses in Patients With Colorectal Cancer
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DOI：
10.1080/01635581.2012.661512
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
McMillan, Donald C.
中科院分区：
文献类型：
--
作者：
Leung, Elaine Y. L.;Roxburgh, Campbell S.;McMillan, Donald C.
B族维生素与癌症发病机制有关。因此，值得关注的是，血浆B6福尔斯作为全身炎症反应（SIR）的一部分而下降，而红细胞浓度则不下降。改良格拉斯哥预后评分（mGPS）是一种经验证的基于炎症的预后评分，由白蛋白和C反应蛋白浓度的组合组成。本研究旨在探讨大肠癌患者血浆和红细胞维生素B浓度与局部和全身炎症反应的关系。对108例结直肠癌患者术前静脉血进行C反应蛋白、白蛋白、黄素腺嘌呤二核苷酸（FAD）、磷酸吡哆醛（PLP）及淋巴细胞计数分析。检索病理切片以评估炎性细胞浸润。增加mGPS与较低的血浆PLP浓度相关（P < 0.01），但与血浆和红细胞FAD和红细胞PLP浓度无关。肿瘤分期的增加与静脉浸润（P < 0.01）和低度炎性细胞浸润（P < 0.05）相关，但与SIR、FAD或PLP浓度无关。低度炎症细胞浸润与任何其他参数均无显着相关性。SIR的存在与结直肠癌患者血浆PLP浓度较低相关，但与红细胞PLP浓度无关。FAD和PLP均与肿瘤炎性细胞浸润无关。
B vitamins have been implicated in cancer pathogenesis. It is therefore of interest that plasma B6 falls as part of the systemic inflammatory response (SIR), whereas red cell concentrations do not. The modified Glasgow Prognostic Score (mGPS) is a validated inflammation-based prognostic score that consists of a combination of albumin and C-reactive protein concentrations. The aim of this study was to examine the relationships between the concentrations of plasma and red cell vitamin B concentrations, the local and systemic inflammatory response in patients with colorectal cancer. Preoperative venous blood of 108 patients with colorectal cancer were analyzed for C-reactive protein, albumin, flavin adenine dinucleotide (FAD), and pyridoxal phosphate (PLP), and lymphocyte counts. Pathological slides were retrieved for assessment of inflammatory cell infiltration. Increasing mGPS was associated with lower plasma PLP concentrations (P < 0.01) but not plasma and red cell FAD and red cell PLP concentrations. Increasing tumor stage was associated with the presence of venous invasion (P < 0.01) and low-grade inflammatory cell infiltrate (P < 0.05) but not the SIR, FAD, or PLP concentrations. A low-grade inflammatory cell infiltrate was not significantly associated with any other parameter. The presence of a SIR was associated with lower concentrations of plasma PLP but not red cell PLP concentrations in patients with colorectal cancer. Neither FAD and PLP were associated with the tumor inflammatory cell infiltrate.