FACTORS INFLUENCING SODIUM AND WATER EXCRETION IN UREMIC MAN
FACTORS INFLUENCING SODIUM AND WATER EXCRETION IN UREMIC MAN
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DOI：
10.1038/ki.1975.15
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发表时间：
1975-01-01
影响因子：
19.6
通讯作者：
FALLS, WF
中科院分区：
文献类型：
--
作者：
YEH, BPY;TOMKO, DJ;FALLS, WF
尿毒症患者尿钠和水排泄的影响因素。研究慢性终末期肾病患者在三种不同的实验操作之前和之后的尿钠和水排泄：通过透析减少尿素溶质负荷，同时维持细胞外液容量（ECFV），透析不改变尿素溶质负荷或ECFV和减少ECFV不改变尿素溶质负荷。钠和水排泄量显著下降与尿素溶质负荷和ECFV的减少相关，但在透析期间，当这两个指标的减少被阻止时，钠和水排泄量并没有下降。在肌酐清除率无任何改变的情况下发生排泄变化。研究表明，溶质负荷和细胞外液体积扩张的程度独立地影响慢性肾脏疾病的钠和水排泄率。它的结论是，在任何给定的患者中，钠和水的总排泄量是直接影响的一些因素，包括溶质负荷，ECFV的程度和肾小球滤过率。
Factors influencing sodium and water excretion in uremic man. Urinary excretion of sodium and water was investigated in patients with chronic end-stage renal disease before and after three different experimental manipulations: reduction in urea solute load by dialysis while extracellular fluid volume (ECFV) was maintained, dialysis without alteration in urea solute load or ECFV and reduction in ECFV without alteration in urea solute load. Sodium and water excretion significantly declined in association with a reduction in both urea solute load and ECFV, but not during a dialysis when reduction on both of these indexes was prevented. The excretory changes occurred in the absence of any alteration in creatinine clearance. The studies suggest that both solute load and the degree of extracellular fluid volume expansion contribute independently to the rate of sodium and water excretion in chronic renal disease. It is concluded that in any given patient the overall excretion of sodium and water is directly influenced by a number of factors including the solute load, the degree of ECFV and the glomerular filtration rate.