Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum
Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum
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DOI：
10.1021/np0204601
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发表时间：
2003-02-01
影响因子：
5.1
通讯作者：
Faulkner, DJ
中科院分区：
文献类型：
--
作者：
Perez, LJ;Faulkner, DJ
菲律宾海鞘 Lissoclinum bistratum 含有已知的代谢物 bistratamides C 和 D，以及六种新型修饰的环状六肽 bistratamides E-J。通过光谱数据的解释阐明了bistratamides E-J的结构，并在臭氧分解和酸催化水解后确定了组成氨基酸的绝对立体化学。 Bistratamides E-J 在 HCT-116 细胞系测定中具有中等细胞毒性。
The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.